Patients with bilateral hippocampal damage show significant impairment in imagining new experiences compared to control subjects. This study demonstrates that amnesic patients with hippocampal damage are unable to construct rich, coherent imagined experiences, lacking spatial coherence and detailed descriptions. The hippocampus is crucial for creating new experiences by providing spatial context, which is essential for binding disparate elements of an experience. The findings suggest that the hippocampus plays a critical role not only in recalling past events but also in imagining new ones, as imagined experiences closely resemble episodic memories. Despite this, patients were able to generate some details, indicating that the deficit is subtle. The study also highlights that the ability to imagine new experiences is not dependent on recent episodic memories, as the scenarios used were based on general semantic knowledge. The results challenge the traditional view that hippocampal function is time-limited and suggest a more enduring role in memory and imagination. The study provides insights into the neural mechanisms underlying episodic memory and imagination, emphasizing the importance of the hippocampus in creating vivid, coherent experiences.Patients with bilateral hippocampal damage show significant impairment in imagining new experiences compared to control subjects. This study demonstrates that amnesic patients with hippocampal damage are unable to construct rich, coherent imagined experiences, lacking spatial coherence and detailed descriptions. The hippocampus is crucial for creating new experiences by providing spatial context, which is essential for binding disparate elements of an experience. The findings suggest that the hippocampus plays a critical role not only in recalling past events but also in imagining new ones, as imagined experiences closely resemble episodic memories. Despite this, patients were able to generate some details, indicating that the deficit is subtle. The study also highlights that the ability to imagine new experiences is not dependent on recent episodic memories, as the scenarios used were based on general semantic knowledge. The results challenge the traditional view that hippocampal function is time-limited and suggest a more enduring role in memory and imagination. The study provides insights into the neural mechanisms underlying episodic memory and imagination, emphasizing the importance of the hippocampus in creating vivid, coherent experiences.