This article, published in The Lancet on June 9, 1973, by Kenneth L. Jones, David W. Smith, Christy N. Ullerland, Ann Pytkowicz Streissguth, and colleagues, reports on a pattern of malformations in eight unrelated children born to chronic alcoholic mothers. These children exhibited similar craniofacial, limb, and cardiovascular defects, along with prenatal-onset growth deficiency and developmental delay. The study highlights the first reported association between maternal alcoholism and aberrant morphogenesis in offspring. The authors emphasize the importance of their findings for physicians and health professionals, alerting them to the potential risks of prenatal alcohol exposure. The article has had a significant impact on scientific research, societal awareness, and public policy, leading to the establishment of warning labels on alcoholic beverages and the creation of organizations dedicated to raising awareness and supporting families affected by fetal alcohol syndrome (FAS).This article, published in The Lancet on June 9, 1973, by Kenneth L. Jones, David W. Smith, Christy N. Ullerland, Ann Pytkowicz Streissguth, and colleagues, reports on a pattern of malformations in eight unrelated children born to chronic alcoholic mothers. These children exhibited similar craniofacial, limb, and cardiovascular defects, along with prenatal-onset growth deficiency and developmental delay. The study highlights the first reported association between maternal alcoholism and aberrant morphogenesis in offspring. The authors emphasize the importance of their findings for physicians and health professionals, alerting them to the potential risks of prenatal alcohol exposure. The article has had a significant impact on scientific research, societal awareness, and public policy, leading to the establishment of warning labels on alcoholic beverages and the creation of organizations dedicated to raising awareness and supporting families affected by fetal alcohol syndrome (FAS).