The Lancet, 9 June 1973. Pattern of malformation in offspring of chronic alcoholic mothers. Kenneth L. Jones, David W. Smith, Christy N. Ulleland, Ann Pytkowicz Streissguth. Summary: Eight unrelated children of three different ethnic groups, all born to mothers who were chronic alcoholics, have a similar pattern of craniofacial, limb, and cardiovascular defects associated with prenatal-onset growth deficiency and developmental delay. This seems to be the first reported association between maternal alcoholism and aberrant morphogenesis in the offspring. The study reports eight children with similar malformations, all born to mothers with chronic alcoholism. The mothers met the criteria for alcoholism as defined by the National Council on Alcoholism. The children showed craniofacial, limb, and cardiovascular defects, as well as growth deficiency and developmental delay. The study highlights the first documented link between maternal alcoholism and fetal malformations. The article also discusses the historical context of fetal alcohol syndrome (FAS), which was first described in this study. The findings have had a significant impact on the scientific community, leading to increased awareness of the effects of alcohol on fetal development. The study has been cited over 1,050 times, indicating its importance in the field of alcohol research. The study has also influenced public policy, leading to warning labels on alcoholic beverages and the establishment of organizations focused on preventing fetal alcohol syndrome. The study has had far-reaching implications in clinical, scientific, societal, and political areas.The Lancet, 9 June 1973. Pattern of malformation in offspring of chronic alcoholic mothers. Kenneth L. Jones, David W. Smith, Christy N. Ulleland, Ann Pytkowicz Streissguth. Summary: Eight unrelated children of three different ethnic groups, all born to mothers who were chronic alcoholics, have a similar pattern of craniofacial, limb, and cardiovascular defects associated with prenatal-onset growth deficiency and developmental delay. This seems to be the first reported association between maternal alcoholism and aberrant morphogenesis in the offspring. The study reports eight children with similar malformations, all born to mothers with chronic alcoholism. The mothers met the criteria for alcoholism as defined by the National Council on Alcoholism. The children showed craniofacial, limb, and cardiovascular defects, as well as growth deficiency and developmental delay. The study highlights the first documented link between maternal alcoholism and fetal malformations. The article also discusses the historical context of fetal alcohol syndrome (FAS), which was first described in this study. The findings have had a significant impact on the scientific community, leading to increased awareness of the effects of alcohol on fetal development. The study has been cited over 1,050 times, indicating its importance in the field of alcohol research. The study has also influenced public policy, leading to warning labels on alcoholic beverages and the establishment of organizations focused on preventing fetal alcohol syndrome. The study has had far-reaching implications in clinical, scientific, societal, and political areas.