Pectin hydrogels have emerged as a promising medium for controlled drug release, offering a wide range of applications and potential in pharmaceutical formulations. Pectin, a versatile biopolymer, is known for its gelling, thickening, and emulsifying properties, making it suitable for various drug delivery systems. The review covers the formulation strategies, crosslinking techniques, and the complex factors influencing drug release from pectin hydrogels. These factors include environmental conditions and drug-specific characteristics. Pectin hydrogels are adaptable across diverse domains, such as oral and transdermal drug delivery, wound healing, tissue engineering, and clinical trials. Despite challenges in standardization and regulatory compliance, the future of pectin hydrogels looks promising, offering new possibilities for advanced drug delivery systems. The review also discusses the advantages and limitations of pectin-based hydrogels, emphasizing their biocompatibility, controlled drug release capabilities, and versatility in formulation. Additionally, it explores the role of hydrogels in controlled drug release, drug entrapment mechanisms, and the influence of various factors on drug loading and release. Case studies and experimental methods are provided to illustrate the development and application of pectin hydrogels in drug delivery, highlighting their potential in targeted cancer treatment and other therapeutic applications.Pectin hydrogels have emerged as a promising medium for controlled drug release, offering a wide range of applications and potential in pharmaceutical formulations. Pectin, a versatile biopolymer, is known for its gelling, thickening, and emulsifying properties, making it suitable for various drug delivery systems. The review covers the formulation strategies, crosslinking techniques, and the complex factors influencing drug release from pectin hydrogels. These factors include environmental conditions and drug-specific characteristics. Pectin hydrogels are adaptable across diverse domains, such as oral and transdermal drug delivery, wound healing, tissue engineering, and clinical trials. Despite challenges in standardization and regulatory compliance, the future of pectin hydrogels looks promising, offering new possibilities for advanced drug delivery systems. The review also discusses the advantages and limitations of pectin-based hydrogels, emphasizing their biocompatibility, controlled drug release capabilities, and versatility in formulation. Additionally, it explores the role of hydrogels in controlled drug release, drug entrapment mechanisms, and the influence of various factors on drug loading and release. Case studies and experimental methods are provided to illustrate the development and application of pectin hydrogels in drug delivery, highlighting their potential in targeted cancer treatment and other therapeutic applications.