This study examines the levels of perceived stress and anxiety among medical students at Helwan University in Egypt. A cross-sectional survey was conducted using a structured questionnaire to assess the main stressors, perceived stress, and anxiety levels. The results indicate that 93% of medical students experienced moderate to high levels of stress, and 54.9% experienced moderate to concerning levels of anxiety. Academic, teaching, social, intrapersonal, group activity, and desire-related stressors were identified as the primary stressors. Risk factors for higher perceived stress included being female, younger age, living away from family, lower academic performance, and having chronic medical illnesses. Risk factors for higher anxiety included being female, residing in rural areas, having chronic medical illnesses, perceiving high levels of stress, and experiencing higher levels of academic, intrapersonal, and social-related stressors. The study concludes that a significant proportion of medical students face various levels of stress and anxiety, highlighting the need for stress management programs to help them cope with different stressors.This study examines the levels of perceived stress and anxiety among medical students at Helwan University in Egypt. A cross-sectional survey was conducted using a structured questionnaire to assess the main stressors, perceived stress, and anxiety levels. The results indicate that 93% of medical students experienced moderate to high levels of stress, and 54.9% experienced moderate to concerning levels of anxiety. Academic, teaching, social, intrapersonal, group activity, and desire-related stressors were identified as the primary stressors. Risk factors for higher perceived stress included being female, younger age, living away from family, lower academic performance, and having chronic medical illnesses. Risk factors for higher anxiety included being female, residing in rural areas, having chronic medical illnesses, perceiving high levels of stress, and experiencing higher levels of academic, intrapersonal, and social-related stressors. The study concludes that a significant proportion of medical students face various levels of stress and anxiety, highlighting the need for stress management programs to help them cope with different stressors.