A cross-sectional study conducted at Helwan University in Egypt found that 93% of medical students experienced moderate to high levels of stress, while 54.9% experienced moderate to concerning levels of anxiety. The main stressors included academic, teaching, social, intrapersonal, group activity, and drive-related stressors. Risk factors for higher stress included being female, younger age, living away from family, lower academic performance, and chronic medical conditions. Risk factors for higher anxiety included being female, living in rural areas, chronic medical conditions, and higher levels of academic and social stressors. The study highlights the need for stress management programs to help medical students cope with stress and anxiety. The findings suggest that academic stress is the leading stressor among medical students, and interventions should focus on reducing academic pressure and providing counseling and academic support. The study also emphasizes the importance of addressing the mental health needs of medical students, particularly those with chronic illnesses. The study's limitations include its single-institution focus and cross-sectional design, which limits the ability to establish causality. Overall, the study underscores the urgent need for targeted interventions to support the mental health of medical students.A cross-sectional study conducted at Helwan University in Egypt found that 93% of medical students experienced moderate to high levels of stress, while 54.9% experienced moderate to concerning levels of anxiety. The main stressors included academic, teaching, social, intrapersonal, group activity, and drive-related stressors. Risk factors for higher stress included being female, younger age, living away from family, lower academic performance, and chronic medical conditions. Risk factors for higher anxiety included being female, living in rural areas, chronic medical conditions, and higher levels of academic and social stressors. The study highlights the need for stress management programs to help medical students cope with stress and anxiety. The findings suggest that academic stress is the leading stressor among medical students, and interventions should focus on reducing academic pressure and providing counseling and academic support. The study also emphasizes the importance of addressing the mental health needs of medical students, particularly those with chronic illnesses. The study's limitations include its single-institution focus and cross-sectional design, which limits the ability to establish causality. Overall, the study underscores the urgent need for targeted interventions to support the mental health of medical students.