Periprosthetic joint infection (PJI) is a significant complication of joint arthroplasty, with an overall incidence of 0.7% in this study. The majority of PJI cases (65%) occurred within the first year after surgery. The most common pathogens were Staphylococcus aureus and Staphylococcus epidermidis. Independent risk factors for PJI included higher American Society of Anesthesiologists (ASA) score, morbid obesity, bilateral arthroplasty, knee arthroplasty, allogenic transfusion, postoperative atrial fibrillation, myocardial infarction, urinary tract infection, and longer hospitalization. These findings confirm previously identified risk factors and highlight new variables that predispose patients to PJI. The study also identified that postoperative atrial fibrillation and myocardial infarction may increase the risk of PJI, possibly due to aggressive anticoagulation. Longer hospital stays were also an independent risk factor, likely due to increased exposure to nosocomial infections. Allogenic blood transfusion was found to be an independent risk factor for PJI, with patients receiving transfusion being 2.1 times more likely to develop PJI. The study emphasizes the importance of identifying and managing these risk factors to reduce the incidence of PJI. The authors have implemented strict preoperative protocols to minimize these risk factors, including preoperative screening for urinary tract infections, blood conservation techniques, and controlled anticoagulation. The study concludes that PJI remains a major challenge and that effective strategies to minimize identified risk factors are essential to reduce its incidence.Periprosthetic joint infection (PJI) is a significant complication of joint arthroplasty, with an overall incidence of 0.7% in this study. The majority of PJI cases (65%) occurred within the first year after surgery. The most common pathogens were Staphylococcus aureus and Staphylococcus epidermidis. Independent risk factors for PJI included higher American Society of Anesthesiologists (ASA) score, morbid obesity, bilateral arthroplasty, knee arthroplasty, allogenic transfusion, postoperative atrial fibrillation, myocardial infarction, urinary tract infection, and longer hospitalization. These findings confirm previously identified risk factors and highlight new variables that predispose patients to PJI. The study also identified that postoperative atrial fibrillation and myocardial infarction may increase the risk of PJI, possibly due to aggressive anticoagulation. Longer hospital stays were also an independent risk factor, likely due to increased exposure to nosocomial infections. Allogenic blood transfusion was found to be an independent risk factor for PJI, with patients receiving transfusion being 2.1 times more likely to develop PJI. The study emphasizes the importance of identifying and managing these risk factors to reduce the incidence of PJI. The authors have implemented strict preoperative protocols to minimize these risk factors, including preoperative screening for urinary tract infections, blood conservation techniques, and controlled anticoagulation. The study concludes that PJI remains a major challenge and that effective strategies to minimize identified risk factors are essential to reduce its incidence.