This review article discusses the development of perovskite oxides for the oxygen evolution reaction (OER), focusing on intellectual design strategies, properties, and future perspectives. Perovskite oxides are promising materials for OER due to their high catalytic activity, stability, and cost-effectiveness. The review highlights various strategies to enhance OER performance, including synthetic modulation, doping, surface engineering, structure mutation, and hybrids. These strategies aim to optimize the physicochemical properties of perovskite oxides, such as electronic structure, metal–oxygen bonding configuration, adsorption capacity of oxygenated species, and electrical conductivity, to improve OER efficiency. The review also discusses the underlying mechanisms of OER, including the adsorbate evolution mechanism (AEM) and the lattice oxygen oxidation mechanism (LOM), and their implications for catalytic activity. The review emphasizes the importance of understanding the relationship between the design strategies and the resulting OER performance, as well as the challenges and potential applications of perovskite oxides in energy conversion and storage systems. The review concludes that perovskite oxides offer a promising alternative to traditional materials for OER, with the potential to significantly improve the efficiency and sustainability of energy systems.This review article discusses the development of perovskite oxides for the oxygen evolution reaction (OER), focusing on intellectual design strategies, properties, and future perspectives. Perovskite oxides are promising materials for OER due to their high catalytic activity, stability, and cost-effectiveness. The review highlights various strategies to enhance OER performance, including synthetic modulation, doping, surface engineering, structure mutation, and hybrids. These strategies aim to optimize the physicochemical properties of perovskite oxides, such as electronic structure, metal–oxygen bonding configuration, adsorption capacity of oxygenated species, and electrical conductivity, to improve OER efficiency. The review also discusses the underlying mechanisms of OER, including the adsorbate evolution mechanism (AEM) and the lattice oxygen oxidation mechanism (LOM), and their implications for catalytic activity. The review emphasizes the importance of understanding the relationship between the design strategies and the resulting OER performance, as well as the challenges and potential applications of perovskite oxides in energy conversion and storage systems. The review concludes that perovskite oxides offer a promising alternative to traditional materials for OER, with the potential to significantly improve the efficiency and sustainability of energy systems.