Personalized Nutrition (PN) is a transformative approach in dietary science that uses individual genetic profiles to guide tailored dietary recommendations, optimizing health outcomes and managing chronic diseases more effectively. This review highlights key aspects of PN, emphasizing the genetic basis of dietary responses, contemporary research, and practical applications. It explores how individual genetic differences influence dietary metabolisms, underscoring the importance of nutrigenomics in developing personalized dietary guidelines. Current research in PN highlights significant gene-diet interactions affecting conditions like obesity and diabetes, suggesting that dietary interventions can be more precise and beneficial when customized to genetic profiles. The review also discusses technological advancements in genetic testing that enable real-time dietary customization and the need for robust integration of bioinformatics and genomics to advance PN. Challenges and ethical concerns, such as data privacy and informed consent, are addressed, along with the potential for PN to revolutionize public health and personalized medicine. The future of PN lies in broader adoption across health and wellness sectors, promising significant advancements in public health and personalized medicine.Personalized Nutrition (PN) is a transformative approach in dietary science that uses individual genetic profiles to guide tailored dietary recommendations, optimizing health outcomes and managing chronic diseases more effectively. This review highlights key aspects of PN, emphasizing the genetic basis of dietary responses, contemporary research, and practical applications. It explores how individual genetic differences influence dietary metabolisms, underscoring the importance of nutrigenomics in developing personalized dietary guidelines. Current research in PN highlights significant gene-diet interactions affecting conditions like obesity and diabetes, suggesting that dietary interventions can be more precise and beneficial when customized to genetic profiles. The review also discusses technological advancements in genetic testing that enable real-time dietary customization and the need for robust integration of bioinformatics and genomics to advance PN. Challenges and ethical concerns, such as data privacy and informed consent, are addressed, along with the potential for PN to revolutionize public health and personalized medicine. The future of PN lies in broader adoption across health and wellness sectors, promising significant advancements in public health and personalized medicine.