Personalized nutrition (PN) is a transformative approach in dietary science that uses individual genetic profiles to tailor dietary recommendations, optimizing health outcomes and managing chronic diseases. This review explores the genetic basis of dietary responses, current research, and practical applications of PN. It emphasizes the importance of nutrigenomics in developing personalized dietary guidelines and highlights gene-diet interactions that influence conditions like obesity and diabetes. The review also discusses technological advancements in genetic testing that enable real-time dietary customization and advocates for the integration of bioinformatics and genomics to advance PN. Challenges such as data privacy, ethical concerns, and the need for multidisciplinary research are addressed. The future of PN lies in its broader adoption across health and wellness sectors, promising significant advancements in public health and personalized medicine. PN has the potential to revolutionize dietary recommendations by considering individual genetic, metabolic, and environmental profiles. However, its full potential requires continued research, collaboration across disciplines, and the development of ethical and legal frameworks to ensure responsible implementation. The review underscores the need for further studies to refine gene-diet interactions and validate PN interventions in diverse populations. It also highlights the importance of balancing the benefits and risks of PN, particularly concerning data privacy, informed consent, and health disparities. The future of PN depends on integrating scientific innovation with ethical responsibility and inclusivity.Personalized nutrition (PN) is a transformative approach in dietary science that uses individual genetic profiles to tailor dietary recommendations, optimizing health outcomes and managing chronic diseases. This review explores the genetic basis of dietary responses, current research, and practical applications of PN. It emphasizes the importance of nutrigenomics in developing personalized dietary guidelines and highlights gene-diet interactions that influence conditions like obesity and diabetes. The review also discusses technological advancements in genetic testing that enable real-time dietary customization and advocates for the integration of bioinformatics and genomics to advance PN. Challenges such as data privacy, ethical concerns, and the need for multidisciplinary research are addressed. The future of PN lies in its broader adoption across health and wellness sectors, promising significant advancements in public health and personalized medicine. PN has the potential to revolutionize dietary recommendations by considering individual genetic, metabolic, and environmental profiles. However, its full potential requires continued research, collaboration across disciplines, and the development of ethical and legal frameworks to ensure responsible implementation. The review underscores the need for further studies to refine gene-diet interactions and validate PN interventions in diverse populations. It also highlights the importance of balancing the benefits and risks of PN, particularly concerning data privacy, informed consent, and health disparities. The future of PN depends on integrating scientific innovation with ethical responsibility and inclusivity.