This review article by Nate Schultheiss and Ann Newman discusses the advancements in pharmaceutical cocrystals over the past decade, highlighting their potential to alter physicochemical properties without compromising the structural integrity of the active pharmaceutical ingredient (API). The authors emphasize the advantages of cocrystals over other solid-state strategies, such as salts, in terms of their broader applicability to APIs regardless of their functional groups. They outline the challenges and considerations in designing and characterizing cocrystals, including the importance of crystal packing and intermolecular interactions. The review also delves into the physical and chemical properties of cocrystals, such as melting point, stability, solubility, dissolution, and bioavailability, providing detailed examples and data from various studies. The authors conclude by discussing the implications of these properties for drug development and the need for further research to optimize cocrystal design and characterization.This review article by Nate Schultheiss and Ann Newman discusses the advancements in pharmaceutical cocrystals over the past decade, highlighting their potential to alter physicochemical properties without compromising the structural integrity of the active pharmaceutical ingredient (API). The authors emphasize the advantages of cocrystals over other solid-state strategies, such as salts, in terms of their broader applicability to APIs regardless of their functional groups. They outline the challenges and considerations in designing and characterizing cocrystals, including the importance of crystal packing and intermolecular interactions. The review also delves into the physical and chemical properties of cocrystals, such as melting point, stability, solubility, dissolution, and bioavailability, providing detailed examples and data from various studies. The authors conclude by discussing the implications of these properties for drug development and the need for further research to optimize cocrystal design and characterization.