Pharmaceutical cocrystals are multicomponent assemblies held together by noncovalent interactions and can alter physicochemical properties of active pharmaceutical ingredients (APIs) without compromising their structure. Over the past decade, cocrystals have gained attention in pharmaceuticals due to their ability to improve solubility, dissolution, and bioavailability. This review discusses the physicochemical properties of cocrystals, including melting point, stability, solubility, and dissolution, and highlights the importance of characterizing cocrystals using techniques such as X-ray diffraction, NMR, and infrared spectroscopy. Cocrystals can be distinguished from salts based on their physicochemical properties, and their stability can be assessed under various conditions, including relative humidity and thermal stress. Chemical stability studies show that cocrystals can be more stable than the parent API, and solution stability is important for ensuring that cocrystals remain in solution and do not crystallize. Solubility studies indicate that cocrystals can improve the solubility of poorly soluble compounds, and dissolution experiments show that cocrystals can enhance dissolution rates compared to individual APIs. Overall, cocrystals offer a promising approach for improving the physicochemical properties of APIs and have the potential to be used in the development of new pharmaceutical formulations.Pharmaceutical cocrystals are multicomponent assemblies held together by noncovalent interactions and can alter physicochemical properties of active pharmaceutical ingredients (APIs) without compromising their structure. Over the past decade, cocrystals have gained attention in pharmaceuticals due to their ability to improve solubility, dissolution, and bioavailability. This review discusses the physicochemical properties of cocrystals, including melting point, stability, solubility, and dissolution, and highlights the importance of characterizing cocrystals using techniques such as X-ray diffraction, NMR, and infrared spectroscopy. Cocrystals can be distinguished from salts based on their physicochemical properties, and their stability can be assessed under various conditions, including relative humidity and thermal stress. Chemical stability studies show that cocrystals can be more stable than the parent API, and solution stability is important for ensuring that cocrystals remain in solution and do not crystallize. Solubility studies indicate that cocrystals can improve the solubility of poorly soluble compounds, and dissolution experiments show that cocrystals can enhance dissolution rates compared to individual APIs. Overall, cocrystals offer a promising approach for improving the physicochemical properties of APIs and have the potential to be used in the development of new pharmaceutical formulations.