The article discusses the pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in enhancing drug delivery. THEDES are formed by mixing drugs with deep eutectic solvents (DESs) in specific molar ratios, offering improved solubility, permeability, and bioavailability of drugs. DESs are non-toxic, cheap, and environmentally friendly, making them suitable for various drug delivery routes, including intravenous (IV), implantable, intramuscular (IM), subcutaneous (SC), ocular, and targeted delivery. The article highlights the fabrication techniques for THEDES, such as electrospinning, self-emulsification, supercritical fluid, nanoprecipitation, and others. It also reviews the pharmaceutical applications of THEDES, including dissolution enhancement of APIs, maximizing drug delivery in treating metabolic and non-metabolic diseases, and fortifying bioactive compounds. The potential of NADES (natural deep eutectic systems) in drug stabilization and extraction is also explored. Overall, the article emphasizes the significance of continued research and innovation in harnessing the full potential of THEDES in pharmaceutical sciences.The article discusses the pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in enhancing drug delivery. THEDES are formed by mixing drugs with deep eutectic solvents (DESs) in specific molar ratios, offering improved solubility, permeability, and bioavailability of drugs. DESs are non-toxic, cheap, and environmentally friendly, making them suitable for various drug delivery routes, including intravenous (IV), implantable, intramuscular (IM), subcutaneous (SC), ocular, and targeted delivery. The article highlights the fabrication techniques for THEDES, such as electrospinning, self-emulsification, supercritical fluid, nanoprecipitation, and others. It also reviews the pharmaceutical applications of THEDES, including dissolution enhancement of APIs, maximizing drug delivery in treating metabolic and non-metabolic diseases, and fortifying bioactive compounds. The potential of NADES (natural deep eutectic systems) in drug stabilization and extraction is also explored. Overall, the article emphasizes the significance of continued research and innovation in harnessing the full potential of THEDES in pharmaceutical sciences.