The article reviews the pharmacological effects of ginseng and ginsenosides on intestinal inflammation and immune system disorders. It highlights how these compounds regulate immune balance, modulate inflammatory mediators and cytokines, promote intestinal mucosal wound healing, prevent colitis-associated colorectal cancer, restore gut microbiota and metabolism, alleviate antibiotic-induced diarrhea, and relieve symptoms of irritable bowel syndrome. The review also discusses the specific experimental methods and key control mechanisms involved in these effects. Ginseng and ginsenosides are emerging as promising therapeutic options for various gastrointestinal disorders due to their strong anti-inflammatory and immunomodulatory properties.The article reviews the pharmacological effects of ginseng and ginsenosides on intestinal inflammation and immune system disorders. It highlights how these compounds regulate immune balance, modulate inflammatory mediators and cytokines, promote intestinal mucosal wound healing, prevent colitis-associated colorectal cancer, restore gut microbiota and metabolism, alleviate antibiotic-induced diarrhea, and relieve symptoms of irritable bowel syndrome. The review also discusses the specific experimental methods and key control mechanisms involved in these effects. Ginseng and ginsenosides are emerging as promising therapeutic options for various gastrointestinal disorders due to their strong anti-inflammatory and immunomodulatory properties.