The article "Pharmacological functions of salidroside in renal diseases: facts and perspectives" by Qiong Liu, Jianzhu Chen, Anqi Zeng, and Linjiang Song provides an in-depth review of the pharmacological roles of salidroside, a key constituent of *Rhodiola rosea*, in the treatment and prevention of renal diseases. Salidroside has been shown to exhibit potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, and anti-aging effects, making it a promising candidate for the management of various renal conditions. The authors discuss the microinflammatory state in kidney disease and highlight recent advancements in using salidroside for renal disease treatment. They outline the potential mechanisms of action of salidroside, which include regulation of gene and protein expression in various renal cells and modulation of multiple signaling pathways such as AMPK/SIRT1, Nrf2/HO-1, Sirt1/PPC-1α, ROS/Src/Cav-1, Akt/GSK-3β, TXNIP-NLRP3, ERK1/2, TGF-β1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a β-catenin, TLR4/NF-κB, MAPK, JAK2/STAT3, and SIRT1/Nrf2. The review also covers the therapeutic effects of salidroside in specific renal diseases, including diabetic nephropathy, acute kidney injury, renal interstitial fibrosis, and renal cell carcinoma. The authors conclude that salidroside has great potential as a drug for the prevention and treatment of metabolic syndrome, cardiovascular and cerebrovascular diseases, and renal complications.The article "Pharmacological functions of salidroside in renal diseases: facts and perspectives" by Qiong Liu, Jianzhu Chen, Anqi Zeng, and Linjiang Song provides an in-depth review of the pharmacological roles of salidroside, a key constituent of *Rhodiola rosea*, in the treatment and prevention of renal diseases. Salidroside has been shown to exhibit potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, and anti-aging effects, making it a promising candidate for the management of various renal conditions. The authors discuss the microinflammatory state in kidney disease and highlight recent advancements in using salidroside for renal disease treatment. They outline the potential mechanisms of action of salidroside, which include regulation of gene and protein expression in various renal cells and modulation of multiple signaling pathways such as AMPK/SIRT1, Nrf2/HO-1, Sirt1/PPC-1α, ROS/Src/Cav-1, Akt/GSK-3β, TXNIP-NLRP3, ERK1/2, TGF-β1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a β-catenin, TLR4/NF-κB, MAPK, JAK2/STAT3, and SIRT1/Nrf2. The review also covers the therapeutic effects of salidroside in specific renal diseases, including diabetic nephropathy, acute kidney injury, renal interstitial fibrosis, and renal cell carcinoma. The authors conclude that salidroside has great potential as a drug for the prevention and treatment of metabolic syndrome, cardiovascular and cerebrovascular diseases, and renal complications.