The review by Ammon and Wahl discusses the pharmacological properties of *Curcuma longa* (turmeric), focusing on its anti-inflammatory, wound healing, gastrointestinal, liver, bile, pancreatic, cardiovascular, hormonal, antimicrobial, antitumor, and toxicological effects. Key findings include: 1. **Anti-inflammatory Activity**: *Curcuma longa* extracts, particularly curcumin and volatile oil, exhibit significant anti-inflammatory activity when administered parenterally. Oral administration of curcumin is less effective due to poor absorption. 2. **Wound Healing**: Turmeric powder has been shown to accelerate wound healing in both septic and aseptic wounds in rats and rabbits. 3. **Gastrointestinal Effects**: Curcumin and the volatile oil may have antispasmodic and antiulcerogenic properties, but the clinical relevance of these effects is questionable due to poor absorption. 4. **Liver and Bile**: *Curcuma longa* extracts protect the liver and stimulate bile secretion, suggesting potential use in liver disorders. 5. **Pancreas**: Studies with synthetic derivatives of curcumin show increased pancreatic bicarbonate output and secretin concentration, indicating a role in pancreatic function. 6. **Cardiovascular System**: Curcumin has a transient hypotensive effect and depresses isolated guinea pig heart, but its clinical significance is unclear. 7. **Anticoagulant Activity**: Curcumin and its analogues exhibit anticoagulant properties, potentially through TXA2 inhibition. 8. **Hormonal and Metabolic Effects**: Curcumin has antifertility and hypolipemic effects, possibly due to its impact on cholesterol metabolism. 9. **Microorganisms**: *Curcuma longa* extracts and curcumin show antibacterial and antifungal activities, but their practical relevance is limited to topical applications. 10. **Toxicity**: Oral administration of curcumin up to 5 g/kg in rats did not cause significant toxic effects, and it is unlikely to have teratogenic activity. 11. **Clinical Studies**: Limited clinical trials suggest that curcumin may improve symptoms in patients with rheumatoid arthritis and respiratory diseases, but more research is needed. The review highlights the need for further scientific investigation to validate the traditional uses of *Curcuma longa* and to understand its mechanisms of action and clinical applications.The review by Ammon and Wahl discusses the pharmacological properties of *Curcuma longa* (turmeric), focusing on its anti-inflammatory, wound healing, gastrointestinal, liver, bile, pancreatic, cardiovascular, hormonal, antimicrobial, antitumor, and toxicological effects. Key findings include: 1. **Anti-inflammatory Activity**: *Curcuma longa* extracts, particularly curcumin and volatile oil, exhibit significant anti-inflammatory activity when administered parenterally. Oral administration of curcumin is less effective due to poor absorption. 2. **Wound Healing**: Turmeric powder has been shown to accelerate wound healing in both septic and aseptic wounds in rats and rabbits. 3. **Gastrointestinal Effects**: Curcumin and the volatile oil may have antispasmodic and antiulcerogenic properties, but the clinical relevance of these effects is questionable due to poor absorption. 4. **Liver and Bile**: *Curcuma longa* extracts protect the liver and stimulate bile secretion, suggesting potential use in liver disorders. 5. **Pancreas**: Studies with synthetic derivatives of curcumin show increased pancreatic bicarbonate output and secretin concentration, indicating a role in pancreatic function. 6. **Cardiovascular System**: Curcumin has a transient hypotensive effect and depresses isolated guinea pig heart, but its clinical significance is unclear. 7. **Anticoagulant Activity**: Curcumin and its analogues exhibit anticoagulant properties, potentially through TXA2 inhibition. 8. **Hormonal and Metabolic Effects**: Curcumin has antifertility and hypolipemic effects, possibly due to its impact on cholesterol metabolism. 9. **Microorganisms**: *Curcuma longa* extracts and curcumin show antibacterial and antifungal activities, but their practical relevance is limited to topical applications. 10. **Toxicity**: Oral administration of curcumin up to 5 g/kg in rats did not cause significant toxic effects, and it is unlikely to have teratogenic activity. 11. **Clinical Studies**: Limited clinical trials suggest that curcumin may improve symptoms in patients with rheumatoid arthritis and respiratory diseases, but more research is needed. The review highlights the need for further scientific investigation to validate the traditional uses of *Curcuma longa* and to understand its mechanisms of action and clinical applications.