PhenoScanner is a curated database and web-based tool designed to facilitate 'phenome scans' by cross-referencing genetic variants with a wide range of phenotypes. The database contains over 350 million association results and 10 million unique genetic variants, primarily single nucleotide polymorphisms (SNPs). It includes results from large-scale genetic association studies and offers a user-friendly interface to query the database for associations with specified variants and their proxies. The tool aligns alleles, calculates linkage disequilibrium measures, and provides results according to the same effect and non-effect alleles for each input variant. This approach enhances the efficiency and interpretability of phenome scans, aiding in understanding disease pathways, biological insights, and therapeutic target identification. PhenoScanner is available at www.phenoscaner.medschl.cam.ac.uk.PhenoScanner is a curated database and web-based tool designed to facilitate 'phenome scans' by cross-referencing genetic variants with a wide range of phenotypes. The database contains over 350 million association results and 10 million unique genetic variants, primarily single nucleotide polymorphisms (SNPs). It includes results from large-scale genetic association studies and offers a user-friendly interface to query the database for associations with specified variants and their proxies. The tool aligns alleles, calculates linkage disequilibrium measures, and provides results according to the same effect and non-effect alleles for each input variant. This approach enhances the efficiency and interpretability of phenome scans, aiding in understanding disease pathways, biological insights, and therapeutic target identification. PhenoScanner is available at www.phenoscaner.medschl.cam.ac.uk.