The article discusses the complex regulatory mechanisms of ultraviolet radiation (UVR) on the body, brain, and immune system. While UVR is commonly recognized for its detrimental effects such as carcinogenesis, skin aging, and autoimmune disorders, its positive role in modulating homeostasis is often overlooked. UVR, particularly ultraviolet B (UVB), triggers local responses through chemical, hormonal, immune, and neural signals, which are coordinated by the cutaneous neuro-immuno-endocrine system. These responses are wavelength-dependent and involve the production of various molecules, including hormones, neurotransmitters, and cytokines, that act on central regulatory centers such as the hypothalamus, pituitary, and adrenal glands. The article highlights the importance of understanding these mechanisms for developing novel therapeutic approaches in various disorders, including addiction, mood disorders, autoimmune diseases, and chronic pain. It also emphasizes the need for computational biology tools and AI to better understand the complex regulatory networks induced by UVR.The article discusses the complex regulatory mechanisms of ultraviolet radiation (UVR) on the body, brain, and immune system. While UVR is commonly recognized for its detrimental effects such as carcinogenesis, skin aging, and autoimmune disorders, its positive role in modulating homeostasis is often overlooked. UVR, particularly ultraviolet B (UVB), triggers local responses through chemical, hormonal, immune, and neural signals, which are coordinated by the cutaneous neuro-immuno-endocrine system. These responses are wavelength-dependent and involve the production of various molecules, including hormones, neurotransmitters, and cytokines, that act on central regulatory centers such as the hypothalamus, pituitary, and adrenal glands. The article highlights the importance of understanding these mechanisms for developing novel therapeutic approaches in various disorders, including addiction, mood disorders, autoimmune diseases, and chronic pain. It also emphasizes the need for computational biology tools and AI to better understand the complex regulatory networks induced by UVR.