This study develops a multifunctional gold-based nanoflower system (PAu@C/B) that combines mild-photothermal therapy (mPTT), photodynamic therapy (PDT), and controlled drug release for the treatment of infectious skin wounds. The nanoflowers are loaded with a photosensitizer (Ce6) for PDT and an anti-inflammatory drug (bromfenac sodium/BS) to promote tissue regeneration. Under laser irradiation, the nanoflowers increase the local temperature to ~45 °C, trigger the release of Ce6 for PDT, and release BS to inhibit inflammation. In vitro, the nanoflowers exhibit high antibacterial efficiency against drug-resistant bacteria and biofilm inhibition. They also show good biocompatibility and improve wound healing in animal models of subcutaneous abscess and skin wounds infected with drug-resistant bacteria. The nanoflowers regulate the immune microenvironment by controlling the release of BS, inhibiting inflammation, and promoting growth factor production, collagen deposition, and angiogenesis. This study provides an advanced nano-system with photo-triggered antimicrobial and anti-inflammatory activities, enhancing infectious skin tissue regeneration.This study develops a multifunctional gold-based nanoflower system (PAu@C/B) that combines mild-photothermal therapy (mPTT), photodynamic therapy (PDT), and controlled drug release for the treatment of infectious skin wounds. The nanoflowers are loaded with a photosensitizer (Ce6) for PDT and an anti-inflammatory drug (bromfenac sodium/BS) to promote tissue regeneration. Under laser irradiation, the nanoflowers increase the local temperature to ~45 °C, trigger the release of Ce6 for PDT, and release BS to inhibit inflammation. In vitro, the nanoflowers exhibit high antibacterial efficiency against drug-resistant bacteria and biofilm inhibition. They also show good biocompatibility and improve wound healing in animal models of subcutaneous abscess and skin wounds infected with drug-resistant bacteria. The nanoflowers regulate the immune microenvironment by controlling the release of BS, inhibiting inflammation, and promoting growth factor production, collagen deposition, and angiogenesis. This study provides an advanced nano-system with photo-triggered antimicrobial and anti-inflammatory activities, enhancing infectious skin tissue regeneration.