A multifunctional gold-based hybrid nanoflower system, PAu@C/B, was developed for infectious skin regeneration. This system combines mild photothermal therapy (mPTT), photodynamic therapy (PDT), and controlled drug release of anti-inflammatory agents. The nanoflowers, synthesized using a template method, incorporate a photosensitizer (Ce6) for PDT and bromfenac sodium (BS) for anti-inflammation. Upon laser irradiation, the nanoflowers generate a mild temperature (~45°C) for mPTT and produce reactive oxygen species (ROS) for PDT, while releasing BS to modulate the inflammatory environment. The system demonstrated high antibacterial efficiency (99%) and biofilm inhibition in vitro. In vivo, it effectively reduced bacterial load, promoted tissue regeneration, and enhanced wound healing in mice with MRSA infections. The nanoflowers also regulated the immune microenvironment by shifting macrophage phenotypes from M1 to M2, promoting angiogenesis and collagen deposition. The combination of mPTT and PDT, along with controlled drug release, provided a synergistic approach for infectious skin regeneration. The system showed excellent biocompatibility and stability, with no significant toxicity observed. This study highlights the potential of PAu@C/B as an advanced nanomaterial for infectious wound healing.A multifunctional gold-based hybrid nanoflower system, PAu@C/B, was developed for infectious skin regeneration. This system combines mild photothermal therapy (mPTT), photodynamic therapy (PDT), and controlled drug release of anti-inflammatory agents. The nanoflowers, synthesized using a template method, incorporate a photosensitizer (Ce6) for PDT and bromfenac sodium (BS) for anti-inflammation. Upon laser irradiation, the nanoflowers generate a mild temperature (~45°C) for mPTT and produce reactive oxygen species (ROS) for PDT, while releasing BS to modulate the inflammatory environment. The system demonstrated high antibacterial efficiency (99%) and biofilm inhibition in vitro. In vivo, it effectively reduced bacterial load, promoted tissue regeneration, and enhanced wound healing in mice with MRSA infections. The nanoflowers also regulated the immune microenvironment by shifting macrophage phenotypes from M1 to M2, promoting angiogenesis and collagen deposition. The combination of mPTT and PDT, along with controlled drug release, provided a synergistic approach for infectious skin regeneration. The system showed excellent biocompatibility and stability, with no significant toxicity observed. This study highlights the potential of PAu@C/B as an advanced nanomaterial for infectious wound healing.