The NNPDF Collaboration has constructed a set of parton distribution functions (PDFs) that include a photon PDF, based on the recent NNPDF4.0 PDF set. The photon PDF is determined using the LuxQED formalism, and QED evolution is implemented and benchmarked using the EKO code. The impact of QED effects on NNPDF4.0 is investigated, and the results are compared to previous NNPDF3.1QED PDF sets and other recent QED PDF sets. The study assesses the impact of photon-initiated processes and electroweak corrections on various LHC processes, finding that they can reach the 5% level in vector boson pair production at large invariant mass. The new determination of QED PDFs is based on a new theory pipeline, which includes an automated process for producing QED variants of NNPDF determinations. The NNPDF4.0QED PDF sets are publicly available via the LHAPDF6 interface.The NNPDF Collaboration has constructed a set of parton distribution functions (PDFs) that include a photon PDF, based on the recent NNPDF4.0 PDF set. The photon PDF is determined using the LuxQED formalism, and QED evolution is implemented and benchmarked using the EKO code. The impact of QED effects on NNPDF4.0 is investigated, and the results are compared to previous NNPDF3.1QED PDF sets and other recent QED PDF sets. The study assesses the impact of photon-initiated processes and electroweak corrections on various LHC processes, finding that they can reach the 5% level in vector boson pair production at large invariant mass. The new determination of QED PDFs is based on a new theory pipeline, which includes an automated process for producing QED variants of NNPDF determinations. The NNPDF4.0QED PDF sets are publicly available via the LHAPDF6 interface.