This study presents a comprehensive phylogenomic analysis of angiosperms, using a standardized set of 353 nuclear genes to build a tree of life for nearly 8,000 angiosperm genera, representing about 60% of all known angiosperm genera. This represents a 15-fold increase in sampling compared to previous nuclear studies. The tree was scaled to time using 200 fossil calibrations, revealing that early angiosperm evolution was characterized by high gene tree conflict and explosive diversification, leading to more than 80% of extant angiosperm orders. Diversification continued steadily through the Mesozoic Era but increased in the Cenozoic Era, coinciding with decreasing global temperatures and gene tree conflict. The study highlights the importance of nuclear genomic data in understanding angiosperm evolution, showing that gene tree conflict is closely linked to diversification. The results support the prevailing angiosperm phylogenetic classification but also reveal some previously unknown relationships. The study underscores the role of botanical collections in reconstructing the tree of life and illuminating long-standing questions in angiosperm macroevolution. The findings suggest that angiosperm diversification was influenced by factors such as climate change, genetic conflict, and hybridization. The study also emphasizes the need for further research to resolve key relationships and understand the processes driving angiosperm diversification. The results provide a foundation for future research on angiosperm evolution and highlight the importance of phylogenomic methods in understanding the complex history of angiosperms.This study presents a comprehensive phylogenomic analysis of angiosperms, using a standardized set of 353 nuclear genes to build a tree of life for nearly 8,000 angiosperm genera, representing about 60% of all known angiosperm genera. This represents a 15-fold increase in sampling compared to previous nuclear studies. The tree was scaled to time using 200 fossil calibrations, revealing that early angiosperm evolution was characterized by high gene tree conflict and explosive diversification, leading to more than 80% of extant angiosperm orders. Diversification continued steadily through the Mesozoic Era but increased in the Cenozoic Era, coinciding with decreasing global temperatures and gene tree conflict. The study highlights the importance of nuclear genomic data in understanding angiosperm evolution, showing that gene tree conflict is closely linked to diversification. The results support the prevailing angiosperm phylogenetic classification but also reveal some previously unknown relationships. The study underscores the role of botanical collections in reconstructing the tree of life and illuminating long-standing questions in angiosperm macroevolution. The findings suggest that angiosperm diversification was influenced by factors such as climate change, genetic conflict, and hybridization. The study also emphasizes the need for further research to resolve key relationships and understand the processes driving angiosperm diversification. The results provide a foundation for future research on angiosperm evolution and highlight the importance of phylogenomic methods in understanding the complex history of angiosperms.