This study investigates the phytochemical constituents of ten medicinal plants commonly used in traditional medicine in South Eastern Nigeria. The plants, including Cleome nutidosperma, Emilia coccinea, Euphorbia heterophylla, Physalis angulata, Richardia bransiliensis, Scopania dulcis, Sida acuta, Spigelia anthelma, Stachytarpheta cayennensis, and Tridax procumbens, were analyzed for the presence of alkaloids, tannins, saponins, steroids, terpenoids, flavonoids, phlobatannins, and cardiac glycosides. The results showed that all plants contained alkaloids and tannins, with the exception of Sida acuta, which lacked tannins, and Stachytarpheta cayennensis, which lacked flavonoids. The study also quantified the percentage of these constituents in each plant, with Sida acuta having the highest yield of alkaloids (1.04%) and Cleome nutidosperma having the lowest (0.32%). The presence of terpenoids was observed in Scopania dulcis, and the study highlights the potential of these plants as sources of bioactive compounds for further research and traditional medicine applications.This study investigates the phytochemical constituents of ten medicinal plants commonly used in traditional medicine in South Eastern Nigeria. The plants, including Cleome nutidosperma, Emilia coccinea, Euphorbia heterophylla, Physalis angulata, Richardia bransiliensis, Scopania dulcis, Sida acuta, Spigelia anthelma, Stachytarpheta cayennensis, and Tridax procumbens, were analyzed for the presence of alkaloids, tannins, saponins, steroids, terpenoids, flavonoids, phlobatannins, and cardiac glycosides. The results showed that all plants contained alkaloids and tannins, with the exception of Sida acuta, which lacked tannins, and Stachytarpheta cayennensis, which lacked flavonoids. The study also quantified the percentage of these constituents in each plant, with Sida acuta having the highest yield of alkaloids (1.04%) and Cleome nutidosperma having the lowest (0.32%). The presence of terpenoids was observed in Scopania dulcis, and the study highlights the potential of these plants as sources of bioactive compounds for further research and traditional medicine applications.