This review explores the role of phytochemicals in drug discovery, focusing on their potential in treating various diseases, including cancer and antimicrobial resistance. Phytochemicals, which are naturally occurring compounds found in plants, have shown significant therapeutic properties due to their structural diversity, chemical novelty, and bioactivity. They are secondary metabolites that play a protective role in plants and have been used for centuries in traditional medicine. The review discusses the importance of phytochemicals in modern drug development, highlighting their potential as effective and safe anticancer agents. It also addresses the challenges in the discovery and development of phytochemical-based drugs, including the need for standardized procedures and the difficulty of isolating pure compounds. The review emphasizes the importance of integrating traditional knowledge with modern scientific methods to enhance the discovery of new drugs. It also discusses the use of advanced technologies such as metabolomics and bioinformatics in the screening and identification of phytochemicals. The review concludes that phytochemicals represent a promising arsenal in the fight against drug resistance and other diseases, and that further research is needed to fully harness their potential in drug discovery.This review explores the role of phytochemicals in drug discovery, focusing on their potential in treating various diseases, including cancer and antimicrobial resistance. Phytochemicals, which are naturally occurring compounds found in plants, have shown significant therapeutic properties due to their structural diversity, chemical novelty, and bioactivity. They are secondary metabolites that play a protective role in plants and have been used for centuries in traditional medicine. The review discusses the importance of phytochemicals in modern drug development, highlighting their potential as effective and safe anticancer agents. It also addresses the challenges in the discovery and development of phytochemical-based drugs, including the need for standardized procedures and the difficulty of isolating pure compounds. The review emphasizes the importance of integrating traditional knowledge with modern scientific methods to enhance the discovery of new drugs. It also discusses the use of advanced technologies such as metabolomics and bioinformatics in the screening and identification of phytochemicals. The review concludes that phytochemicals represent a promising arsenal in the fight against drug resistance and other diseases, and that further research is needed to fully harness their potential in drug discovery.