This review discusses the role of phytochemicals in mitigating the toxic effects of heavy metals (HMs) on human health. HMs, such as lead, mercury, cadmium, and arsenic, are naturally occurring elements that can accumulate in the environment and enter the food chain, posing serious health risks. While chelation therapy is an effective treatment for HM poisoning, it can have side effects. Dietary components and phytoantioxidants have been shown to play a significant role in preventing or reducing HM-induced damage. This review summarizes the role of various phytochemicals, plant and herbal extracts, and probiotics in promoting human health by mitigating the toxic effects of different HMs. Phytochemicals such as flavonoids, curcumin, ferulic acid, and ellagic acid have been shown to reduce HM toxicity through their antioxidant, metal-chelating, and anti-inflammatory properties. Flavonoids, including quercetin, hesperidin, and hesperetin, have been found to reduce oxidative stress and apoptosis caused by HMs. Curcumin, a polyphenolic compound found in turmeric, has been shown to reduce HM-induced toxicity by scavenging reactive oxygen species (ROS) and modulating antioxidant pathways. Ferulic acid and ellagic acid also exhibit protective effects against HM-induced toxicity by reducing oxidative stress and DNA damage. Plant and herbal extracts, such as those from garlic, Centella asiatica, and Aloe vera, have been studied for their ability to reduce HM-induced toxicity. Spirulina, a blue-green algae, has been shown to have chelating properties and can reduce the levels of HMs in the body. Ginger, a common spice, has also been investigated for its potential to reduce HM-induced toxicity through its antioxidant and anti-inflammatory properties. In conclusion, phytochemicals and plant extracts offer promising alternatives to traditional chelation therapy for mitigating the toxic effects of HMs. Further research is needed to fully understand the mechanisms of action and to determine the optimal dosages and treatment durations for these natural compounds.This review discusses the role of phytochemicals in mitigating the toxic effects of heavy metals (HMs) on human health. HMs, such as lead, mercury, cadmium, and arsenic, are naturally occurring elements that can accumulate in the environment and enter the food chain, posing serious health risks. While chelation therapy is an effective treatment for HM poisoning, it can have side effects. Dietary components and phytoantioxidants have been shown to play a significant role in preventing or reducing HM-induced damage. This review summarizes the role of various phytochemicals, plant and herbal extracts, and probiotics in promoting human health by mitigating the toxic effects of different HMs. Phytochemicals such as flavonoids, curcumin, ferulic acid, and ellagic acid have been shown to reduce HM toxicity through their antioxidant, metal-chelating, and anti-inflammatory properties. Flavonoids, including quercetin, hesperidin, and hesperetin, have been found to reduce oxidative stress and apoptosis caused by HMs. Curcumin, a polyphenolic compound found in turmeric, has been shown to reduce HM-induced toxicity by scavenging reactive oxygen species (ROS) and modulating antioxidant pathways. Ferulic acid and ellagic acid also exhibit protective effects against HM-induced toxicity by reducing oxidative stress and DNA damage. Plant and herbal extracts, such as those from garlic, Centella asiatica, and Aloe vera, have been studied for their ability to reduce HM-induced toxicity. Spirulina, a blue-green algae, has been shown to have chelating properties and can reduce the levels of HMs in the body. Ginger, a common spice, has also been investigated for its potential to reduce HM-induced toxicity through its antioxidant and anti-inflammatory properties. In conclusion, phytochemicals and plant extracts offer promising alternatives to traditional chelation therapy for mitigating the toxic effects of HMs. Further research is needed to fully understand the mechanisms of action and to determine the optimal dosages and treatment durations for these natural compounds.