This review article explores the principles, manufacturing techniques, and applications of piezotronic neuromorphic devices. These devices modulate electrical transport characteristics by piezopotential, directly associating external mechanical motion with electrical output signals. The review classifies piezotronic neuromorphic devices into strain-gated piezotronic transistors and piezoelectric nanogenerator-gated field effect transistors, discussing their operating mechanisms and fabrication methods. Recent research progress is summarized, highlighting multifunctional applications such as bionic sensing, information storage, logic computing, and artificial synapses. The article also discusses future challenges and perspectives, emphasizing the potential of piezotronic neuromorphic devices in advancing interactive sensation, memory, and computation for the Internet of Things, AI, and biomedical engineering.This review article explores the principles, manufacturing techniques, and applications of piezotronic neuromorphic devices. These devices modulate electrical transport characteristics by piezopotential, directly associating external mechanical motion with electrical output signals. The review classifies piezotronic neuromorphic devices into strain-gated piezotronic transistors and piezoelectric nanogenerator-gated field effect transistors, discussing their operating mechanisms and fabrication methods. Recent research progress is summarized, highlighting multifunctional applications such as bionic sensing, information storage, logic computing, and artificial synapses. The article also discusses future challenges and perspectives, emphasizing the potential of piezotronic neuromorphic devices in advancing interactive sensation, memory, and computation for the Internet of Things, AI, and biomedical engineering.