This comprehensive review explores the synthesis and pharmacological potential of silver nanoparticles (AgNPs) produced using plant extracts. The article highlights the advantages of plant-mediated synthesis, including cost-effectiveness, reduced synthesis time, and environmental sustainability. AgNPs have gained significant attention due to their exceptional properties, particularly in medicine. The review covers various medicinal attributes of AgNPs, such as antimicrobial activity, cytotoxicity, wound healing, larvicidal effects, anti-angiogenesis activity, antioxidant potential, and antiplasmodial activity. The mechanisms underlying these pharmacological actions are also discussed. The synthesis methods, characterization techniques, and the role of plant extracts in the production of AgNPs are detailed, emphasizing the importance of reducing harmful by-products and enhancing biocompatibility. The review concludes by highlighting the potential of AgNPs in addressing healthcare challenges, such as antibiotic resistance and cancer treatment, and their broader applications in wound healing, bone repair, and vector control.This comprehensive review explores the synthesis and pharmacological potential of silver nanoparticles (AgNPs) produced using plant extracts. The article highlights the advantages of plant-mediated synthesis, including cost-effectiveness, reduced synthesis time, and environmental sustainability. AgNPs have gained significant attention due to their exceptional properties, particularly in medicine. The review covers various medicinal attributes of AgNPs, such as antimicrobial activity, cytotoxicity, wound healing, larvicidal effects, anti-angiogenesis activity, antioxidant potential, and antiplasmodial activity. The mechanisms underlying these pharmacological actions are also discussed. The synthesis methods, characterization techniques, and the role of plant extracts in the production of AgNPs are detailed, emphasizing the importance of reducing harmful by-products and enhancing biocompatibility. The review concludes by highlighting the potential of AgNPs in addressing healthcare challenges, such as antibiotic resistance and cancer treatment, and their broader applications in wound healing, bone repair, and vector control.