The article provides an extensive overview of plant phenolics, their extraction, analysis, and their antioxidant and anticancer properties. Phenolic compounds, which are abundant in plants, have gained significant attention due to their potent antioxidant properties and potential in preventing oxidative stress-related diseases like cancer. The review covers the extraction methods, including solvent extractions, microwave-assisted extraction, ultrasound-assisted extraction, and pressurized fluid extraction, each with its advantages and limitations. It also discusses the purification and fractionation techniques, such as solid-phase extraction and column chromatography, used to isolate and concentrate phenolic compounds. The analysis and quantification of phenolics are addressed, highlighting various methods like the Folin-Ciocalteu assay, UV/VIS spectroscopy, and high-performance liquid chromatography (HPLC). The antioxidant properties of phenolics are explored, including their ability to scavenge free radicals, chelate metals, and their potential prooxidant activity under certain conditions. The article concludes by discussing the determination of total antioxidant capacity (TAC) of phenolic extracts using assays like TEAC, ORAC, and FRAP.The article provides an extensive overview of plant phenolics, their extraction, analysis, and their antioxidant and anticancer properties. Phenolic compounds, which are abundant in plants, have gained significant attention due to their potent antioxidant properties and potential in preventing oxidative stress-related diseases like cancer. The review covers the extraction methods, including solvent extractions, microwave-assisted extraction, ultrasound-assisted extraction, and pressurized fluid extraction, each with its advantages and limitations. It also discusses the purification and fractionation techniques, such as solid-phase extraction and column chromatography, used to isolate and concentrate phenolic compounds. The analysis and quantification of phenolics are addressed, highlighting various methods like the Folin-Ciocalteu assay, UV/VIS spectroscopy, and high-performance liquid chromatography (HPLC). The antioxidant properties of phenolics are explored, including their ability to scavenge free radicals, chelate metals, and their potential prooxidant activity under certain conditions. The article concludes by discussing the determination of total antioxidant capacity (TAC) of phenolic extracts using assays like TEAC, ORAC, and FRAP.