Plasma-surface modification (PSM) is an effective and economical technique for enhancing the surface properties and biocompatibility of biomedical materials while maintaining their bulk attributes. This review article discusses various plasma techniques, including plasma sputtering, etching, implantation, deposition, polymerization, laser plasma deposition, and spraying. These techniques can selectively modify the surface properties of materials, such as wettability, adhesion, and biocompatibility, without altering the bulk properties. The article highlights the advantages of PSM, such as reliability, reproducibility, and applicability to different materials and geometries. It also provides examples of applications in hard tissue replacements, blood-contacting prostheses, ophthalmic devices, and other biomedical products. The review covers the principles, methods, and recent advancements in PSM, emphasizing its importance in improving the performance and longevity of biomedical devices.Plasma-surface modification (PSM) is an effective and economical technique for enhancing the surface properties and biocompatibility of biomedical materials while maintaining their bulk attributes. This review article discusses various plasma techniques, including plasma sputtering, etching, implantation, deposition, polymerization, laser plasma deposition, and spraying. These techniques can selectively modify the surface properties of materials, such as wettability, adhesion, and biocompatibility, without altering the bulk properties. The article highlights the advantages of PSM, such as reliability, reproducibility, and applicability to different materials and geometries. It also provides examples of applications in hard tissue replacements, blood-contacting prostheses, ophthalmic devices, and other biomedical products. The review covers the principles, methods, and recent advancements in PSM, emphasizing its importance in improving the performance and longevity of biomedical devices.