PlasmoDB is a functional genomic database for *Plasmodium spp.*, providing comprehensive data and visualization tools for gene-by-gene or genome-wide analysis. The latest release, PlasmoDB 5.5, includes annotated genomes, transcription evidence, proteomics data, protein function annotations, population biology, and evolution information from eight *Plasmodium* species. Users can query data through a query grid or drop-down menus, combine results using a query history page, and download data with associated functional information. The database supports complex queries and integrates various data types, facilitating research on the life cycle, gene expression, and protein function of *Plasmodium* parasites. Future developments include expanding data content, incorporating new datasets, and enhancing the user interface for a more intuitive and dynamic experience.PlasmoDB is a functional genomic database for *Plasmodium spp.*, providing comprehensive data and visualization tools for gene-by-gene or genome-wide analysis. The latest release, PlasmoDB 5.5, includes annotated genomes, transcription evidence, proteomics data, protein function annotations, population biology, and evolution information from eight *Plasmodium* species. Users can query data through a query grid or drop-down menus, combine results using a query history page, and download data with associated functional information. The database supports complex queries and integrates various data types, facilitating research on the life cycle, gene expression, and protein function of *Plasmodium* parasites. Future developments include expanding data content, incorporating new datasets, and enhancing the user interface for a more intuitive and dynamic experience.