The article "Point of Care Diagnostics: Status and Future" by Gubala et al. (2011) reviews the current state and future prospects of point-of-care (POC) diagnostics. POC diagnostics are in vitro diagnostic tests that do not require laboratory staff or facilities to provide results. These tests can be used in hospitals, clinics, homes, or in the field to monitor health, manage diseases, or test water and food safety. The article highlights the importance of rapid, accurate, and reliable POC diagnostics, emphasizing their role in saving time, improving patient compliance, and reducing medical costs. The review covers various analytical targets, including proteins, nucleic acids, metabolites, drugs, and microbes, and discusses the different classes of bioanalytical targets. It also provides an overview of well-established POC tests such as glucose and pregnancy tests, and recent advancements in key enabling technologies, including lateral flow assays, printing and laminating technologies, microfluidic advances, surface chemistry, and detection methods. The article discusses the limitations of traditional POC approaches, such as errors and interferences, and the importance of reliable measurement targets. It also explores enabling technologies like printing and laminating, microfluidic technologies, pumping and valving, and low-cost pumping mechanisms. The review concludes with a discussion on the future trends and perspectives in POC diagnostics, emphasizing the need for further development to address challenges in accuracy, reliability, and cost-effectiveness.The article "Point of Care Diagnostics: Status and Future" by Gubala et al. (2011) reviews the current state and future prospects of point-of-care (POC) diagnostics. POC diagnostics are in vitro diagnostic tests that do not require laboratory staff or facilities to provide results. These tests can be used in hospitals, clinics, homes, or in the field to monitor health, manage diseases, or test water and food safety. The article highlights the importance of rapid, accurate, and reliable POC diagnostics, emphasizing their role in saving time, improving patient compliance, and reducing medical costs. The review covers various analytical targets, including proteins, nucleic acids, metabolites, drugs, and microbes, and discusses the different classes of bioanalytical targets. It also provides an overview of well-established POC tests such as glucose and pregnancy tests, and recent advancements in key enabling technologies, including lateral flow assays, printing and laminating technologies, microfluidic advances, surface chemistry, and detection methods. The article discusses the limitations of traditional POC approaches, such as errors and interferences, and the importance of reliable measurement targets. It also explores enabling technologies like printing and laminating, microfluidic technologies, pumping and valving, and low-cost pumping mechanisms. The review concludes with a discussion on the future trends and perspectives in POC diagnostics, emphasizing the need for further development to address challenges in accuracy, reliability, and cost-effectiveness.