The US National Institutes of Health (NIH) is addressing the growing concern over the lack of reproducibility in biomedical research. Led by Francis S. Collins and Lawrence A. Tabak, the NIH is exploring several initiatives to enhance the self-correcting nature of preclinical research. These initiatives include developing training modules on reproducibility and transparency, implementing checklists for grant applications, and promoting greater transparency in data access. The NIH is also working with various stakeholders, such as scientific publishers, universities, and industry, to encourage practices that support reproducibility. Additionally, the NIH is considering changes to the peer-review process to reduce unconscious bias and modifying grant mechanisms to provide more stability for investigators. The NIH emphasizes that success in addressing this issue requires the full engagement of the entire biomedical-research community.The US National Institutes of Health (NIH) is addressing the growing concern over the lack of reproducibility in biomedical research. Led by Francis S. Collins and Lawrence A. Tabak, the NIH is exploring several initiatives to enhance the self-correcting nature of preclinical research. These initiatives include developing training modules on reproducibility and transparency, implementing checklists for grant applications, and promoting greater transparency in data access. The NIH is also working with various stakeholders, such as scientific publishers, universities, and industry, to encourage practices that support reproducibility. Additionally, the NIH is considering changes to the peer-review process to reduce unconscious bias and modifying grant mechanisms to provide more stability for investigators. The NIH emphasizes that success in addressing this issue requires the full engagement of the entire biomedical-research community.