Poly Lactic-co-Glycolic Acid (PLGA) is a biocompatible and biodegradable polymer widely used in drug delivery and tissue engineering applications. This review discusses the various fabrication techniques for PLGA devices, including microparticle preparation techniques such as solvent evaporation, phase separation, and spray drying, as well as nanoparticle and implant preparation techniques. The degradation and drug release behavior of PLGA are influenced by factors such as polymer composition, crystallinity, molecular weight, drug type, size and shape of the matrix, pH, enzymes, and drug load. The biodegradation process of PLGA involves bulk diffusion, surface diffusion, bulk erosion, and surface erosion, leading to a biphasic release profile. The review also highlights the potential of PLGA in multi-drug delivery and multifunctional applications, and discusses the toxicological considerations and modeling of drug release profiles. Overall, PLGA is a versatile and effective material for controlled drug delivery due to its tunable properties and biodegradability.Poly Lactic-co-Glycolic Acid (PLGA) is a biocompatible and biodegradable polymer widely used in drug delivery and tissue engineering applications. This review discusses the various fabrication techniques for PLGA devices, including microparticle preparation techniques such as solvent evaporation, phase separation, and spray drying, as well as nanoparticle and implant preparation techniques. The degradation and drug release behavior of PLGA are influenced by factors such as polymer composition, crystallinity, molecular weight, drug type, size and shape of the matrix, pH, enzymes, and drug load. The biodegradation process of PLGA involves bulk diffusion, surface diffusion, bulk erosion, and surface erosion, leading to a biphasic release profile. The review also highlights the potential of PLGA in multi-drug delivery and multifunctional applications, and discusses the toxicological considerations and modeling of drug release profiles. Overall, PLGA is a versatile and effective material for controlled drug delivery due to its tunable properties and biodegradability.