A wireless theranostic patch is developed for managing diabetic wounds, integrating smart hydrogels and wearable bioelectronics to enable real-time monitoring and targeted treatment. The patch features a multifunctional conductive polymer hydrogel (MFCPH) that provides a moist, antimicrobial environment, supports glucose and pH monitoring, and enables on-demand insulin delivery via iontophoresis and electrical stimulation. The MFCPH, composed of polydopamine-doped polypyrrole nanofibrils in a polyacrylamide network, exhibits high drug loading, conductivity, and broad-spectrum antimicrobial properties. The system includes a smartphone app, wearable electronics, and Thera-patch for continuous monitoring and autonomous drug delivery. The patch can detect pH and glucose levels, enabling real-time adjustments to treatment. In vitro tests demonstrated the sensor's high sensitivity, selectivity, and stability, while in vivo trials on diabetic rats showed improved wound healing, reduced inflammation, and effective glucose control. The Thera-patch with iontophoresis significantly outperformed other groups, achieving rapid wound closure and optimal healing. The system offers a personalized, efficient approach to diabetic wound management, combining real-time monitoring with targeted therapy to enhance healing and reduce infection risks.A wireless theranostic patch is developed for managing diabetic wounds, integrating smart hydrogels and wearable bioelectronics to enable real-time monitoring and targeted treatment. The patch features a multifunctional conductive polymer hydrogel (MFCPH) that provides a moist, antimicrobial environment, supports glucose and pH monitoring, and enables on-demand insulin delivery via iontophoresis and electrical stimulation. The MFCPH, composed of polydopamine-doped polypyrrole nanofibrils in a polyacrylamide network, exhibits high drug loading, conductivity, and broad-spectrum antimicrobial properties. The system includes a smartphone app, wearable electronics, and Thera-patch for continuous monitoring and autonomous drug delivery. The patch can detect pH and glucose levels, enabling real-time adjustments to treatment. In vitro tests demonstrated the sensor's high sensitivity, selectivity, and stability, while in vivo trials on diabetic rats showed improved wound healing, reduced inflammation, and effective glucose control. The Thera-patch with iontophoresis significantly outperformed other groups, achieving rapid wound closure and optimal healing. The system offers a personalized, efficient approach to diabetic wound management, combining real-time monitoring with targeted therapy to enhance healing and reduce infection risks.