14 February 2024 | Nadine Couti, Alina Porfire, Rares Iovanov, Andrea Gabriela Crisan, Sonia Iurian, Tibor Casian and Ioan Tomuță
This review discusses the versatile use of polyvinyl alcohol (PVA) as an excipient in pharmaceutical 3D printing, particularly in fused deposition modeling (FDM). PVA is a widely used polymer in pharmaceutical applications due to its physical and chemical properties, such as water solubility, biodegradability, and biocompatibility. The review highlights the diverse dosage forms that can be created using PVA, including immediate release tablets, sustained release tablets, and special designs like caplets and orodispersible tablets. It also addresses the challenges and solutions in formulation and processing, such as rheological properties, drug-polymer compatibility, and the impact of plasticizers. The study emphasizes the potential of PVA in 3D printing for personalized and tailored pharmaceutical products, overcoming limitations in traditional manufacturing methods.This review discusses the versatile use of polyvinyl alcohol (PVA) as an excipient in pharmaceutical 3D printing, particularly in fused deposition modeling (FDM). PVA is a widely used polymer in pharmaceutical applications due to its physical and chemical properties, such as water solubility, biodegradability, and biocompatibility. The review highlights the diverse dosage forms that can be created using PVA, including immediate release tablets, sustained release tablets, and special designs like caplets and orodispersible tablets. It also addresses the challenges and solutions in formulation and processing, such as rheological properties, drug-polymer compatibility, and the impact of plasticizers. The study emphasizes the potential of PVA in 3D printing for personalized and tailored pharmaceutical products, overcoming limitations in traditional manufacturing methods.