This study introduces a functional MRI method for estimating population receptive fields (pRFs) in human visual cortex. The method uses a model of the fMRI response to estimate the visual field map, pRF size, and laterality. It improves upon conventional visual field mapping by providing more accurate visual field maps and quantifying pRF sizes in different visual areas. The pRF method is non-invasive and can be applied to various conditions where fMRI signals need to be linked to neuronal receptive fields. The study reports quantitative estimates of pRF sizes in medial, lateral, and ventral occipital regions of human visual cortex, showing that pRF sizes in LO and VO are significantly larger than in V1–V3. The pRF method also quantifies input from ipsi- and contralateral visual fields. The results show that pRF sizes increase with eccentricity in V1–V3 and that pRFs are lateralized in V1–V3 but not in LO and VO. The method is compared with electrophysiological measurements and shows good agreement. The study highlights the importance of using a model-based approach to accurately estimate pRF properties and improve the understanding of visual processing in the brain.This study introduces a functional MRI method for estimating population receptive fields (pRFs) in human visual cortex. The method uses a model of the fMRI response to estimate the visual field map, pRF size, and laterality. It improves upon conventional visual field mapping by providing more accurate visual field maps and quantifying pRF sizes in different visual areas. The pRF method is non-invasive and can be applied to various conditions where fMRI signals need to be linked to neuronal receptive fields. The study reports quantitative estimates of pRF sizes in medial, lateral, and ventral occipital regions of human visual cortex, showing that pRF sizes in LO and VO are significantly larger than in V1–V3. The pRF method also quantifies input from ipsi- and contralateral visual fields. The results show that pRF sizes increase with eccentricity in V1–V3 and that pRFs are lateralized in V1–V3 but not in LO and VO. The method is compared with electrophysiological measurements and shows good agreement. The study highlights the importance of using a model-based approach to accurately estimate pRF properties and improve the understanding of visual processing in the brain.