The article reviews the impact of the COVID-19 pandemic on antimicrobial resistance (AMR) globally. It highlights that AMR incidence increased significantly in both in-hospital and outpatient populations, affecting both bacteria and fungi. The initial rise in AMR was driven by the misuse of antibiotics and preventive measures during the pandemic, particularly in hospitalized patients. The easing of lockdowns and the use of personal protective equipment (PPE) led to the spread of resistant microorganisms from low-income countries to other regions, resulting in the emergence of new multi- and poly-resistant organisms. However, there is no clear association between COVID-19 and the changes in AMR in the post-pandemic period. The article emphasizes the need for an integrated supranational monitoring approach and a rational, personalized, and regulated use of antibiotics and antimicrobials to address the ongoing challenge of AMR.The article reviews the impact of the COVID-19 pandemic on antimicrobial resistance (AMR) globally. It highlights that AMR incidence increased significantly in both in-hospital and outpatient populations, affecting both bacteria and fungi. The initial rise in AMR was driven by the misuse of antibiotics and preventive measures during the pandemic, particularly in hospitalized patients. The easing of lockdowns and the use of personal protective equipment (PPE) led to the spread of resistant microorganisms from low-income countries to other regions, resulting in the emergence of new multi- and poly-resistant organisms. However, there is no clear association between COVID-19 and the changes in AMR in the post-pandemic period. The article emphasizes the need for an integrated supranational monitoring approach and a rational, personalized, and regulated use of antibiotics and antimicrobials to address the ongoing challenge of AMR.