This narrative review provides a comprehensive overview of the post-intensive care syndrome (PICS) follow-up system after hospital discharge, emphasizing the importance of long-term management for PICS patients. The review highlights the evolution of PICS follow-up clinics, which began in the UK in 1993 and have since spread globally. However, there is limited evidence on the efficacy of these clinics, with recent studies suggesting that multidisciplinary team approaches, including physicians, nurses, physical therapists, pharmacists, and psychologists, are crucial for effective management. The review discusses various follow-up methods, such as face-to-face assessments, home visits, telephone interviews, and telemedicine, each with its advantages and challenges. It also addresses the assessment instruments used for PICS, including physical, cognitive, and mental health evaluations, and the treatment interventions, such as medication adjustments, rehabilitation, and nutrition therapy. The review concludes by emphasizing the need for increased awareness, education, and financial support to promote the implementation of PICS follow-up systems.This narrative review provides a comprehensive overview of the post-intensive care syndrome (PICS) follow-up system after hospital discharge, emphasizing the importance of long-term management for PICS patients. The review highlights the evolution of PICS follow-up clinics, which began in the UK in 1993 and have since spread globally. However, there is limited evidence on the efficacy of these clinics, with recent studies suggesting that multidisciplinary team approaches, including physicians, nurses, physical therapists, pharmacists, and psychologists, are crucial for effective management. The review discusses various follow-up methods, such as face-to-face assessments, home visits, telephone interviews, and telemedicine, each with its advantages and challenges. It also addresses the assessment instruments used for PICS, including physical, cognitive, and mental health evaluations, and the treatment interventions, such as medication adjustments, rehabilitation, and nutrition therapy. The review concludes by emphasizing the need for increased awareness, education, and financial support to promote the implementation of PICS follow-up systems.