This review highlights the potential of postbiotics, which are non-living microorganisms or their derived components, as biotherapeutic agents for various metabolic disorders. Postbiotics, also known as metabiotics, include cell-free supernatants, exopolysaccharides, antioxidant enzymes, cell wall fragments, short-chain fatty acids (SCFAs), and metabolites from intestinal microbiota. They offer advantages over probiotics, particularly in vulnerable populations such as neonates, premature infants, and immunocompromised individuals. Postbiotics can modulate the resident microbiota, improve epithelial barrier functions, and influence local and systemic immune responses and metabolic responses. They have been shown to have anti-inflammatory, antibacterial, immunomodulatory, and anti-obesogenic effects. In children, postbiotics like fermented infant formulas and specific strains of *Lactobacillus* and *Bifidobacterium* have been effective in improving gut health and reducing the risk of infections. For adults with metabolic disorders, postbiotics can help regulate lipid metabolism, reduce inflammation, and improve insulin sensitivity. Key components of postbiotics, such as cell wall components, polysaccharides, cell-free supernatants, extracellular vesicles, SCFAs, enzymes, bacteriocins, vitamins, and cell-free lyzates, have been studied for their therapeutic potential. These components exhibit various biological activities, including anti-inflammatory, antioxidant, and immunomodulatory effects, which contribute to their beneficial health outcomes. Overall, postbiotics show promise in addressing metabolic disorders and improving human health.This review highlights the potential of postbiotics, which are non-living microorganisms or their derived components, as biotherapeutic agents for various metabolic disorders. Postbiotics, also known as metabiotics, include cell-free supernatants, exopolysaccharides, antioxidant enzymes, cell wall fragments, short-chain fatty acids (SCFAs), and metabolites from intestinal microbiota. They offer advantages over probiotics, particularly in vulnerable populations such as neonates, premature infants, and immunocompromised individuals. Postbiotics can modulate the resident microbiota, improve epithelial barrier functions, and influence local and systemic immune responses and metabolic responses. They have been shown to have anti-inflammatory, antibacterial, immunomodulatory, and anti-obesogenic effects. In children, postbiotics like fermented infant formulas and specific strains of *Lactobacillus* and *Bifidobacterium* have been effective in improving gut health and reducing the risk of infections. For adults with metabolic disorders, postbiotics can help regulate lipid metabolism, reduce inflammation, and improve insulin sensitivity. Key components of postbiotics, such as cell wall components, polysaccharides, cell-free supernatants, extracellular vesicles, SCFAs, enzymes, bacteriocins, vitamins, and cell-free lyzates, have been studied for their therapeutic potential. These components exhibit various biological activities, including anti-inflammatory, antioxidant, and immunomodulatory effects, which contribute to their beneficial health outcomes. Overall, postbiotics show promise in addressing metabolic disorders and improving human health.