This comprehensive review of Postintensive Care Syndrome Family (PICS-F) addresses the concept, risk factors, assessment tools, prevalence, and management to prevent PICS-F. PICS-F is described as a devastated life encompassing psychological, physical, and socioeconomic burdens that begin with the emotional impact experienced by families when their relatives are admitted to the intensive care unit (ICU). The review highlights that PICS-F should be extended beyond psychological impairments to include physical and socioeconomic impairments. Risk factors for PICS-F include patient-related factors (e.g., severity of illness, delirium, prolonged ICU stay), family-related factors (e.g., demographic characteristics, financial insufficiency), and protective factors (e.g., unsatisfactory communication with healthcare providers, higher family resilience). Assessment tools for PICS-F include the Hospital Anxiety and Depression Scale, PTSD Checklist, and the Inventory of Complicated Grief. The review also discusses the importance of providing families with accurate information, using communication facilitators, and offering grief care support. A continuous bundle of multifaceted and multidisciplinary interventions is recommended to prevent PICS-F, including providing family information leaflets, ICU diaries, communication facilitators, and follow-up support. The review emphasizes the need for further research to establish effective interventions and address the limitations of current studies.This comprehensive review of Postintensive Care Syndrome Family (PICS-F) addresses the concept, risk factors, assessment tools, prevalence, and management to prevent PICS-F. PICS-F is described as a devastated life encompassing psychological, physical, and socioeconomic burdens that begin with the emotional impact experienced by families when their relatives are admitted to the intensive care unit (ICU). The review highlights that PICS-F should be extended beyond psychological impairments to include physical and socioeconomic impairments. Risk factors for PICS-F include patient-related factors (e.g., severity of illness, delirium, prolonged ICU stay), family-related factors (e.g., demographic characteristics, financial insufficiency), and protective factors (e.g., unsatisfactory communication with healthcare providers, higher family resilience). Assessment tools for PICS-F include the Hospital Anxiety and Depression Scale, PTSD Checklist, and the Inventory of Complicated Grief. The review also discusses the importance of providing families with accurate information, using communication facilitators, and offering grief care support. A continuous bundle of multifaceted and multidisciplinary interventions is recommended to prevent PICS-F, including providing family information leaflets, ICU diaries, communication facilitators, and follow-up support. The review emphasizes the need for further research to establish effective interventions and address the limitations of current studies.