Postpartum depression significantly affects early mother-infant interactions, parenting, and safety practices. Depressed mothers show less sensitivity and responsiveness to their infants, leading to disrupted interactions. These disturbances are universal across cultures and socioeconomic groups. Caregiving activities, including feeding, sleep routines, and well-child visits, are also compromised. Early interventions such as psychotherapy, interaction coaching, and infant massage are recommended. Postpartum depression is associated with long-term negative effects on children's health and development. Statistics indicate that about 20–40% of mothers and a lower percentage of fathers experience postpartum depression. Depressed mothers may use harsh punishment and have thoughts of harming their infants. Safety practices are also affected, with less use of car seats and safety measures. Universal screening for maternal and paternal depression is crucial during the postpartum period. Early interventions should focus on improving mother-infant interactions. While pharmaceuticals and psychotherapy are used, their effectiveness is mixed. Interaction coaching and infant massage have shown promise in improving interactions and reducing maternal depression. Methodological limitations include reliance on self-report measures and potential confounding factors. Further research is needed to improve understanding and interventions for postpartum depression.Postpartum depression significantly affects early mother-infant interactions, parenting, and safety practices. Depressed mothers show less sensitivity and responsiveness to their infants, leading to disrupted interactions. These disturbances are universal across cultures and socioeconomic groups. Caregiving activities, including feeding, sleep routines, and well-child visits, are also compromised. Early interventions such as psychotherapy, interaction coaching, and infant massage are recommended. Postpartum depression is associated with long-term negative effects on children's health and development. Statistics indicate that about 20–40% of mothers and a lower percentage of fathers experience postpartum depression. Depressed mothers may use harsh punishment and have thoughts of harming their infants. Safety practices are also affected, with less use of car seats and safety measures. Universal screening for maternal and paternal depression is crucial during the postpartum period. Early interventions should focus on improving mother-infant interactions. While pharmaceuticals and psychotherapy are used, their effectiveness is mixed. Interaction coaching and infant massage have shown promise in improving interactions and reducing maternal depression. Methodological limitations include reliance on self-report measures and potential confounding factors. Further research is needed to improve understanding and interventions for postpartum depression.