This paper reviews studies from the last decade on the effects of postpartum depression on early interactions, parenting, safety practices, and early interventions. The review highlights that interaction disturbances between depressed mothers and their infants are universal across different cultures and socioeconomic status groups, characterized by reduced maternal sensitivity and infant responsivity. Postpartum depression also compromises caregiving activities such as feeding practices (especially breastfeeding), sleep routines, well-child visits, vaccinations, and safety practices. The need for universal screening of maternal and paternal depression during the postpartum period is emphasized, along with early interventions like psychotherapy, interaction coaching, and infant massage. The long-term negative outcomes of postpartum depression, including behavioral, emotional, and health problems in children, are attributed to disturbed mother-infant interactions and poor parenting and safety practices. The paper also discusses the clinical implications for pediatric healthcare professionals, including the importance of universal screening and anticipatory guidance. Finally, it suggests the need for further observational research and studies on educational and therapeutic interventions.This paper reviews studies from the last decade on the effects of postpartum depression on early interactions, parenting, safety practices, and early interventions. The review highlights that interaction disturbances between depressed mothers and their infants are universal across different cultures and socioeconomic status groups, characterized by reduced maternal sensitivity and infant responsivity. Postpartum depression also compromises caregiving activities such as feeding practices (especially breastfeeding), sleep routines, well-child visits, vaccinations, and safety practices. The need for universal screening of maternal and paternal depression during the postpartum period is emphasized, along with early interventions like psychotherapy, interaction coaching, and infant massage. The long-term negative outcomes of postpartum depression, including behavioral, emotional, and health problems in children, are attributed to disturbed mother-infant interactions and poor parenting and safety practices. The paper also discusses the clinical implications for pediatric healthcare professionals, including the importance of universal screening and anticipatory guidance. Finally, it suggests the need for further observational research and studies on educational and therapeutic interventions.