The article "Potential Benefits and Risks Associated with the Use of Statins" by Nisha Khatiwada and Zhongkui Hong provides a comprehensive overview of the mechanisms, benefits, and risks associated with statin therapy. Statins, primarily used to treat cardiovascular diseases, offer various pleiotropic effects, including improved endothelial function, anti-inflammatory properties, reduced oxidative stress, anti-thrombotic effects, and stabilization of atherosclerotic plaques. However, their use can also lead to adverse effects such as muscle symptoms (SAMS), type 2 diabetes, liver toxicity, kidney diseases, cataracts, hemorrhagic strokes, and psychiatric complications. These side effects, though relatively infrequent, can significantly impact patient outcomes and necessitate dose adjustments or discontinuation of statin therapy. The review highlights the importance of understanding these side effects and their underlying mechanisms for early detection, prevention, and management. It also emphasizes the need for a patient-centered approach, precision medicine, and combination therapies to optimize statin therapy and improve patient outcomes.The article "Potential Benefits and Risks Associated with the Use of Statins" by Nisha Khatiwada and Zhongkui Hong provides a comprehensive overview of the mechanisms, benefits, and risks associated with statin therapy. Statins, primarily used to treat cardiovascular diseases, offer various pleiotropic effects, including improved endothelial function, anti-inflammatory properties, reduced oxidative stress, anti-thrombotic effects, and stabilization of atherosclerotic plaques. However, their use can also lead to adverse effects such as muscle symptoms (SAMS), type 2 diabetes, liver toxicity, kidney diseases, cataracts, hemorrhagic strokes, and psychiatric complications. These side effects, though relatively infrequent, can significantly impact patient outcomes and necessitate dose adjustments or discontinuation of statin therapy. The review highlights the importance of understanding these side effects and their underlying mechanisms for early detection, prevention, and management. It also emphasizes the need for a patient-centered approach, precision medicine, and combination therapies to optimize statin therapy and improve patient outcomes.