Carotenoids are a diverse group of isoprenoid pigments that play a crucial role in protecting organisms from oxidative stress. They are efficient quenchers of singlet oxygen and scavengers of other reactive oxygen species (ROS), which can cause oxidative damage in various biological systems. Despite not being synthesized by humans and animals, carotenoids are present in their blood and tissues and contribute to several biochemical processes. The antioxidant potential of carotenoids is significant for human health, as the imbalance between ROS production and detoxification can lead to "oxidative stress" and chronic diseases such as cancer, cardiovascular disease, and photosensitivity disorders. Epidemiological studies and clinical trials suggest that adequate carotenoid supplementation can significantly reduce the risk of these disorders. Carotenoids, particularly β-carotene, lycopene, lutein, and zeaxanthin, have been shown to protect against cancer, cardiovascular disease, and eye-related disorders. However, the exact mechanisms of carotenoid action and their interactions with other antioxidants are still not fully understood. Further research is needed to fully elucidate the relationship between carotenoids and ROS-mediated disorders.Carotenoids are a diverse group of isoprenoid pigments that play a crucial role in protecting organisms from oxidative stress. They are efficient quenchers of singlet oxygen and scavengers of other reactive oxygen species (ROS), which can cause oxidative damage in various biological systems. Despite not being synthesized by humans and animals, carotenoids are present in their blood and tissues and contribute to several biochemical processes. The antioxidant potential of carotenoids is significant for human health, as the imbalance between ROS production and detoxification can lead to "oxidative stress" and chronic diseases such as cancer, cardiovascular disease, and photosensitivity disorders. Epidemiological studies and clinical trials suggest that adequate carotenoid supplementation can significantly reduce the risk of these disorders. Carotenoids, particularly β-carotene, lycopene, lutein, and zeaxanthin, have been shown to protect against cancer, cardiovascular disease, and eye-related disorders. However, the exact mechanisms of carotenoid action and their interactions with other antioxidants are still not fully understood. Further research is needed to fully elucidate the relationship between carotenoids and ROS-mediated disorders.