Zika virus (ZIKV) can be transmitted sexually, as demonstrated by a 2013 study in French Polynesia. A 44-year-old man with ZIKV symptoms had ZIKV isolated from his semen, supporting sexual transmission. ZIKV is a mosquito-borne flavivirus first identified in 1947. It causes symptoms like fever, rash, and joint pain, with severe complications reported in some cases. The study found high ZIKV RNA levels in semen and urine, with replicative virus in semen but not in urine. ZIKV was not detected in blood, suggesting viral replication in the genital tract. The patient had no acute symptoms during hematospermia, indicating viremia occurred before. This finding aligns with other flavivirus studies showing viral shedding in urine. ZIKV transmission through sexual contact is possible, and urine samples may be useful for late diagnosis. The study confirms ZIKV can be transmitted sexually, with implications for public health. The research was approved by the Ethics Committee of French Polynesia. The authors are medical professionals specializing in infectious diseases. The study highlights the need for further research on ZIKV transmission routes.Zika virus (ZIKV) can be transmitted sexually, as demonstrated by a 2013 study in French Polynesia. A 44-year-old man with ZIKV symptoms had ZIKV isolated from his semen, supporting sexual transmission. ZIKV is a mosquito-borne flavivirus first identified in 1947. It causes symptoms like fever, rash, and joint pain, with severe complications reported in some cases. The study found high ZIKV RNA levels in semen and urine, with replicative virus in semen but not in urine. ZIKV was not detected in blood, suggesting viral replication in the genital tract. The patient had no acute symptoms during hematospermia, indicating viremia occurred before. This finding aligns with other flavivirus studies showing viral shedding in urine. ZIKV transmission through sexual contact is possible, and urine samples may be useful for late diagnosis. The study confirms ZIKV can be transmitted sexually, with implications for public health. The research was approved by the Ethics Committee of French Polynesia. The authors are medical professionals specializing in infectious diseases. The study highlights the need for further research on ZIKV transmission routes.