Curcumin, a polyphenolic compound derived from Curcuma longa L., has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties, making it effective for treating skin diseases such as psoriasis, scleroderma, atopic dermatitis, and skin infections. It exhibits antiviral, antimutagenic, and antifungal effects and protects against UVB-induced skin damage. Curcumin reduces wound healing time, improves collagen deposition, and increases fibroblast and vascular density in wounds. However, its low bioavailability after oral administration and metabolism limit its effectiveness. To enhance bioavailability, various formulations such as nanoemulsions, liposomes, and chitosan-alginate microcapsules have been developed. These formulations improve curcumin's penetration into the skin and its therapeutic potential for inflammatory skin conditions. In psoriasis, curcumin inhibits the IL-23/T17 pathway, reduces inflammation, and modulates NF-κB activity. Clinical trials show that curcumin improves symptoms and quality of life in patients with psoriasis. In scleroderma, curcumin acts as an anti-fibrotic agent by modulating the TGF-β/Smad pathway and inhibiting collagen production. It also modulates PKC signaling, which is involved in fibrosis. In atopic dermatitis, curcumin reduces inflammation, oxidative stress, and skin barrier damage. It has shown efficacy in reducing symptoms in experimental models and in clinical trials. For iatrogenic dermatitis, curcumin protects against radiation-induced skin damage and promotes wound healing. In wound healing, curcumin reduces inflammation, oxidative stress, and promotes tissue repair. It enhances collagen deposition and improves wound closure. In skin infections, curcumin exhibits antibacterial and antifungal properties, inhibiting bacterial growth and biofilm formation. It also shows synergistic effects when combined with antibiotics or antifungals. Curcumin's antioxidant and anti-inflammatory properties make it a promising agent for treating various skin diseases. However, further clinical trials are needed to confirm its efficacy and safety.Curcumin, a polyphenolic compound derived from Curcuma longa L., has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties, making it effective for treating skin diseases such as psoriasis, scleroderma, atopic dermatitis, and skin infections. It exhibits antiviral, antimutagenic, and antifungal effects and protects against UVB-induced skin damage. Curcumin reduces wound healing time, improves collagen deposition, and increases fibroblast and vascular density in wounds. However, its low bioavailability after oral administration and metabolism limit its effectiveness. To enhance bioavailability, various formulations such as nanoemulsions, liposomes, and chitosan-alginate microcapsules have been developed. These formulations improve curcumin's penetration into the skin and its therapeutic potential for inflammatory skin conditions. In psoriasis, curcumin inhibits the IL-23/T17 pathway, reduces inflammation, and modulates NF-κB activity. Clinical trials show that curcumin improves symptoms and quality of life in patients with psoriasis. In scleroderma, curcumin acts as an anti-fibrotic agent by modulating the TGF-β/Smad pathway and inhibiting collagen production. It also modulates PKC signaling, which is involved in fibrosis. In atopic dermatitis, curcumin reduces inflammation, oxidative stress, and skin barrier damage. It has shown efficacy in reducing symptoms in experimental models and in clinical trials. For iatrogenic dermatitis, curcumin protects against radiation-induced skin damage and promotes wound healing. In wound healing, curcumin reduces inflammation, oxidative stress, and promotes tissue repair. It enhances collagen deposition and improves wound closure. In skin infections, curcumin exhibits antibacterial and antifungal properties, inhibiting bacterial growth and biofilm formation. It also shows synergistic effects when combined with antibiotics or antifungals. Curcumin's antioxidant and anti-inflammatory properties make it a promising agent for treating various skin diseases. However, further clinical trials are needed to confirm its efficacy and safety.