The article discusses the potential of curcumin, a polyphenolic compound derived from *Curcuma longa* L., in the management of various skin diseases. Curcumin exhibits anti-inflammatory, antioxidant, antimicrobial, antiviral, and antifungal properties, making it beneficial for treating conditions such as psoriasis, scleroderma, atopic dermatitis, iatrogenic dermatitis, wound healing, and skin infections. It has been shown to reduce inflammation, improve wound healing, and protect against UVB radiation. Despite its therapeutic potential, curcumin's low bioavailability and poor solubility pose challenges. Various formulations, including nanoemulsions, liposomes, and nanoparticles, have been developed to enhance its bioavailability and efficacy. The article highlights the need for further clinical trials to confirm curcumin's effectiveness in treating skin diseases. It also outlines the molecular mechanisms of curcumin's action, such as inhibition of NF-κB and TGF-β/Smad pathways, and its role in modulating immune responses and oxidative stress. The review emphasizes the importance of curcumin as a natural, cost-effective, and well-tolerated therapeutic agent for various dermatological conditions.The article discusses the potential of curcumin, a polyphenolic compound derived from *Curcuma longa* L., in the management of various skin diseases. Curcumin exhibits anti-inflammatory, antioxidant, antimicrobial, antiviral, and antifungal properties, making it beneficial for treating conditions such as psoriasis, scleroderma, atopic dermatitis, iatrogenic dermatitis, wound healing, and skin infections. It has been shown to reduce inflammation, improve wound healing, and protect against UVB radiation. Despite its therapeutic potential, curcumin's low bioavailability and poor solubility pose challenges. Various formulations, including nanoemulsions, liposomes, and nanoparticles, have been developed to enhance its bioavailability and efficacy. The article highlights the need for further clinical trials to confirm curcumin's effectiveness in treating skin diseases. It also outlines the molecular mechanisms of curcumin's action, such as inhibition of NF-κB and TGF-β/Smad pathways, and its role in modulating immune responses and oxidative stress. The review emphasizes the importance of curcumin as a natural, cost-effective, and well-tolerated therapeutic agent for various dermatological conditions.