The Practice Guidelines for the Management of Infectious Diarrhea emphasize the importance of accurate diagnosis and appropriate treatment to manage this common and often severe condition. With the increasing number of recognized enteric pathogens and the need for cost-effective care, clinical and public health guidelines are essential. Adequate fluid and electrolyte replacement is critical in managing diarrheal illnesses. A thorough clinical and epidemiological evaluation is necessary to determine the severity and type of illness, exposures, and whether the patient is immunocompromised. This helps guide the performance of selective diagnostic tests, toxin testing, and antimicrobial therapy. The guidelines recommend oral rehydration, clinical and epidemiological evaluation, selective fecal studies, and the administration of selective antimicrobial therapy. They also emphasize the importance of avoiding undercooked meat, seafood, and unpasteurized milk to prevent infectious diarrhea. The guidelines also highlight the need for public health surveillance and the importance of identifying and controlling outbreaks. The guidelines are based on extensive research and are intended to provide clinicians and public health practitioners with a consensus-based document that will aid in the management of acute diarrhea. They address the diagnosis, treatment, and prevention of infectious diarrhea, and are intended to evolve as new information becomes available. The guidelines also emphasize the importance of public health actions in controlling the spread of infectious diarrhea. The guidelines are intended to provide a working framework for clinicians and public health providers and should not override or be construed as a substitute for sound clinical decision-making. The guidelines are based on the best available evidence and provide indications regarding the quality of available evidence and the degree of certainty for a given recommendation. They also identify areas where key research questions remain unanswered and emphasize the need for periodic revisions to maintain the relevance of the guidelines.The Practice Guidelines for the Management of Infectious Diarrhea emphasize the importance of accurate diagnosis and appropriate treatment to manage this common and often severe condition. With the increasing number of recognized enteric pathogens and the need for cost-effective care, clinical and public health guidelines are essential. Adequate fluid and electrolyte replacement is critical in managing diarrheal illnesses. A thorough clinical and epidemiological evaluation is necessary to determine the severity and type of illness, exposures, and whether the patient is immunocompromised. This helps guide the performance of selective diagnostic tests, toxin testing, and antimicrobial therapy. The guidelines recommend oral rehydration, clinical and epidemiological evaluation, selective fecal studies, and the administration of selective antimicrobial therapy. They also emphasize the importance of avoiding undercooked meat, seafood, and unpasteurized milk to prevent infectious diarrhea. The guidelines also highlight the need for public health surveillance and the importance of identifying and controlling outbreaks. The guidelines are based on extensive research and are intended to provide clinicians and public health practitioners with a consensus-based document that will aid in the management of acute diarrhea. They address the diagnosis, treatment, and prevention of infectious diarrhea, and are intended to evolve as new information becomes available. The guidelines also emphasize the importance of public health actions in controlling the spread of infectious diarrhea. The guidelines are intended to provide a working framework for clinicians and public health providers and should not override or be construed as a substitute for sound clinical decision-making. The guidelines are based on the best available evidence and provide indications regarding the quality of available evidence and the degree of certainty for a given recommendation. They also identify areas where key research questions remain unanswered and emphasize the need for periodic revisions to maintain the relevance of the guidelines.