2000 | John H. Rex, Thomas J. Walsh, Jack D. Sobel, Scott G. Filler, Peter G. Pappas, William E. Dismukes, John E. Edwards
The guidelines provide recommendations for the treatment of various forms of candidiasis. They emphasize the importance of microbiology laboratory testing to guide treatment, particularly for non-albicans species of Candida. Invasive candidiasis is treated with amphotericin B and azoles, with the choice depending on the species and patient factors. Mucocutaneous candidiasis is primarily treated with azoles, while prevention strategies are recommended for high-risk patients. The guidelines also discuss the use of lipid-based amphotericin B preparations, which are less toxic but more expensive. For pediatric patients, dosing considerations are important due to differences in pharmacokinetics. The guidelines cover various forms of candidiasis, including candidemia, acute hematogenously disseminated candidiasis, chronic disseminated candidiasis, and candidal infections of the urinary tract, lungs, larynx, bones, joints, and abdomen. Treatment options, outcomes, evidence, values, benefits, harms, and costs are discussed for each condition. The guidelines recommend specific therapies based on the clinical situation, species of Candida, and patient factors, with a focus on effective and safe treatment.The guidelines provide recommendations for the treatment of various forms of candidiasis. They emphasize the importance of microbiology laboratory testing to guide treatment, particularly for non-albicans species of Candida. Invasive candidiasis is treated with amphotericin B and azoles, with the choice depending on the species and patient factors. Mucocutaneous candidiasis is primarily treated with azoles, while prevention strategies are recommended for high-risk patients. The guidelines also discuss the use of lipid-based amphotericin B preparations, which are less toxic but more expensive. For pediatric patients, dosing considerations are important due to differences in pharmacokinetics. The guidelines cover various forms of candidiasis, including candidemia, acute hematogenously disseminated candidiasis, chronic disseminated candidiasis, and candidal infections of the urinary tract, lungs, larynx, bones, joints, and abdomen. Treatment options, outcomes, evidence, values, benefits, harms, and costs are discussed for each condition. The guidelines recommend specific therapies based on the clinical situation, species of Candida, and patient factors, with a focus on effective and safe treatment.