The PRISMA statement is an updated version of the QUOROM guidelines for reporting systematic reviews and meta-analyses. It was developed to improve the quality and clarity of reporting in these types of studies. The PRISMA checklist includes 27 items and a four-phase flow diagram, which help authors systematically report their reviews. The checklist emphasizes transparency, completeness, and consistency in reporting, and includes items such as registration of the review, description of study selection processes, and reporting of potential biases. The PRISMA statement was developed through a collaborative effort involving researchers, methodologists, clinicians, and editors. The process involved a systematic review of existing literature, a comprehensive search for relevant articles, and an international survey of review authors and stakeholders. The final checklist was revised multiple times based on feedback and evidence from other domains. The PRISMA statement aims to help authors improve the reporting of systematic reviews and meta-analyses, particularly for randomized trials. It can also be used for other types of research, including evaluations of interventions, diagnostic studies, and policy-making. However, it is not a quality assessment tool for systematic reviews. The PRISMA statement replaces the QUOROM statement for journals that have endorsed it. It is open-access and available on the PRISMA website. The statement is supported by a detailed explanation and elaboration document, which provides examples, rationales, and evidence for each checklist item. This document is intended to assist authors and educators in understanding and applying the PRISMA guidelines. PRISMA is a living document and is open to comments and suggestions from the research community. The statement is endorsed by a wide range of organizations and individuals, including the Cochrane Collaboration, the International Network of Agencies for Health Technology Assessment, and the Guidelines International Network. The PRISMA statement is published in several journals and is freely accessible online.The PRISMA statement is an updated version of the QUOROM guidelines for reporting systematic reviews and meta-analyses. It was developed to improve the quality and clarity of reporting in these types of studies. The PRISMA checklist includes 27 items and a four-phase flow diagram, which help authors systematically report their reviews. The checklist emphasizes transparency, completeness, and consistency in reporting, and includes items such as registration of the review, description of study selection processes, and reporting of potential biases. The PRISMA statement was developed through a collaborative effort involving researchers, methodologists, clinicians, and editors. The process involved a systematic review of existing literature, a comprehensive search for relevant articles, and an international survey of review authors and stakeholders. The final checklist was revised multiple times based on feedback and evidence from other domains. The PRISMA statement aims to help authors improve the reporting of systematic reviews and meta-analyses, particularly for randomized trials. It can also be used for other types of research, including evaluations of interventions, diagnostic studies, and policy-making. However, it is not a quality assessment tool for systematic reviews. The PRISMA statement replaces the QUOROM statement for journals that have endorsed it. It is open-access and available on the PRISMA website. The statement is supported by a detailed explanation and elaboration document, which provides examples, rationales, and evidence for each checklist item. This document is intended to assist authors and educators in understanding and applying the PRISMA guidelines. PRISMA is a living document and is open to comments and suggestions from the research community. The statement is endorsed by a wide range of organizations and individuals, including the Cochrane Collaboration, the International Network of Agencies for Health Technology Assessment, and the Guidelines International Network. The PRISMA statement is published in several journals and is freely accessible online.