Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome

Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome

Received for publication August 24, 2003; revised October 12, 2003; accepted November 18, 2003 | Shell F. Wong, MD, a,* Kam M. Chow, MD, a Tse N. Leung, PhD, b Wai F. Ng, MD, c Tak K. Ng, MD, d Chi C. Shek, MD, e Pak C. Ng, f Pansy W. Y. Lam, MD, a Lau C. Ho, MD, a William W. K. To, MD, g Sik T. Lai, MD, h Wing W. Yan, MD, i Peggy Y. H. Tan, MD j
The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. The centre is hosted on Elsevier Connect and grants permission for all COVID-19-related research to be made available in PubMed Central and other public repositories, with unrestricted reuse and analysis rights. A study evaluating pregnancy and perinatal outcomes of pregnant women with severe acute respiratory syndrome (SARS) was conducted. Between February 1 and July 31, 2003, 12 pregnant women with SARS were included. The study found a 25% case fatality rate, with 57% of first-trimester patients experiencing spontaneous miscarriage and 80% of patients presenting after 24 weeks being delivered preterm. Two mothers recovered without delivery but had intrauterine growth restriction in their ongoing pregnancies. No newborn infants showed clinical SARS or evidence of perinatal SARS infection. The study highlights the high maternal morbidity and mortality associated with SARS during pregnancy, including spontaneous miscarriage, preterm delivery, and intrauterine growth restriction. Despite close contact with SARS virus, there was no evidence of vertical transmission to infants. The findings provide valuable insights for managing pregnant women with SARS.The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. The centre is hosted on Elsevier Connect and grants permission for all COVID-19-related research to be made available in PubMed Central and other public repositories, with unrestricted reuse and analysis rights. A study evaluating pregnancy and perinatal outcomes of pregnant women with severe acute respiratory syndrome (SARS) was conducted. Between February 1 and July 31, 2003, 12 pregnant women with SARS were included. The study found a 25% case fatality rate, with 57% of first-trimester patients experiencing spontaneous miscarriage and 80% of patients presenting after 24 weeks being delivered preterm. Two mothers recovered without delivery but had intrauterine growth restriction in their ongoing pregnancies. No newborn infants showed clinical SARS or evidence of perinatal SARS infection. The study highlights the high maternal morbidity and mortality associated with SARS during pregnancy, including spontaneous miscarriage, preterm delivery, and intrauterine growth restriction. Despite close contact with SARS virus, there was no evidence of vertical transmission to infants. The findings provide valuable insights for managing pregnant women with SARS.
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