HIV-infected individuals have a higher prevalence of noninfectious comorbidities (NICMs) compared to the general population. A study compared HIV-infected patients with age-, sex-, and race-matched controls and found that HIV-infected patients had higher rates of NICMs, including cardiovascular disease, hypertension, diabetes, bone fractures, and renal failure. Polypathology (Pp), defined as the presence of ≥2 NICMs, was also more common in HIV-infected patients. Logistic regression models identified independent predictors of Pp as age, male sex, lower nadir CD4 cell count, and ART exposure. These findings suggest that HIV-specific factors contribute to premature aging and increased risk of NICMs in HIV-infected individuals. The study highlights the need for earlier screening and intervention for NICMs in HIV-infected patients. The widespread use of effective antiretroviral therapy (ART) has reduced HIV-related mortality but not all deaths are due to HIV itself. Many HIV-infected individuals die from noninfectious comorbidities, including cardiovascular disease, hypertension, diabetes, and renal failure. These conditions are often associated with aging in the general population but occur earlier in HIV-infected individuals. The study suggests that HIV-specific factors, such as lower nadir CD4 cell count and prolonged ART exposure, contribute to this premature aging. The findings support the need for earlier screening for NICMs in HIV-infected patients. The study also found that the prevalence of Pp in HIV-infected individuals was similar to that in the general population 10 years older. This indicates that HIV-infected individuals may benefit from earlier screening and interventions to prevent common age-related NICMs. The study also found that hypertension was strongly associated with the presence of other NICMs. The results suggest that an aggressive approach to screening, diagnosis, and treatment of NICMs is needed for HIV-infected patients. The study also highlights the importance of considering HIV-specific factors when assessing the risk of NICMs in HIV-infected individuals. The study has limitations, including potential selection bias and differences in methods for detecting NICMs between patients and controls. Despite these limitations, the study provides important insights into the increased risk of NICMs in HIV-infected individuals and the need for earlier screening and intervention.HIV-infected individuals have a higher prevalence of noninfectious comorbidities (NICMs) compared to the general population. A study compared HIV-infected patients with age-, sex-, and race-matched controls and found that HIV-infected patients had higher rates of NICMs, including cardiovascular disease, hypertension, diabetes, bone fractures, and renal failure. Polypathology (Pp), defined as the presence of ≥2 NICMs, was also more common in HIV-infected patients. Logistic regression models identified independent predictors of Pp as age, male sex, lower nadir CD4 cell count, and ART exposure. These findings suggest that HIV-specific factors contribute to premature aging and increased risk of NICMs in HIV-infected individuals. The study highlights the need for earlier screening and intervention for NICMs in HIV-infected patients. The widespread use of effective antiretroviral therapy (ART) has reduced HIV-related mortality but not all deaths are due to HIV itself. Many HIV-infected individuals die from noninfectious comorbidities, including cardiovascular disease, hypertension, diabetes, and renal failure. These conditions are often associated with aging in the general population but occur earlier in HIV-infected individuals. The study suggests that HIV-specific factors, such as lower nadir CD4 cell count and prolonged ART exposure, contribute to this premature aging. The findings support the need for earlier screening for NICMs in HIV-infected patients. The study also found that the prevalence of Pp in HIV-infected individuals was similar to that in the general population 10 years older. This indicates that HIV-infected individuals may benefit from earlier screening and interventions to prevent common age-related NICMs. The study also found that hypertension was strongly associated with the presence of other NICMs. The results suggest that an aggressive approach to screening, diagnosis, and treatment of NICMs is needed for HIV-infected patients. The study also highlights the importance of considering HIV-specific factors when assessing the risk of NICMs in HIV-infected individuals. The study has limitations, including potential selection bias and differences in methods for detecting NICMs between patients and controls. Despite these limitations, the study provides important insights into the increased risk of NICMs in HIV-infected individuals and the need for earlier screening and intervention.