A population-based cohort study of 1134 mother-child pairs from six European countries found that prenatal exposure to endocrine-disrupting chemicals (EDCs) was associated with an increased risk of metabolic syndrome (MetS) in children. The study examined nine chemical classes, including metals, organochlorine pesticides, polybrominated diphenyl ethers (PBDEs), and perfluoroalkyl substances (PFAS), and found that higher exposure levels were linked to increased MetS risk scores. Conversely, high- and low-molecular weight phthalate mixtures were associated with lower MetS scores. The study also identified associations between EDC exposure and elevated levels of proinflammatory proteins, amino acids, and altered glycerophospholipids, which were linked to increased MetS risk. The findings suggest that exposure to widespread EDC mixtures during pregnancy may contribute to adverse metabolic health in children and could play a role in the ongoing rise of MetS across the life course. The study used a Bayesian weighted quantile sum regression approach to assess the associations between EDC mixtures and MetS risk scores, and identified specific chemical contributors to these associations. The study also found sex-specific effects, with certain chemicals having different associations in males and females. Overall, the study highlights the importance of considering EDC mixtures in assessing health risks and underscores the need for further research to understand the mechanisms underlying these associations.A population-based cohort study of 1134 mother-child pairs from six European countries found that prenatal exposure to endocrine-disrupting chemicals (EDCs) was associated with an increased risk of metabolic syndrome (MetS) in children. The study examined nine chemical classes, including metals, organochlorine pesticides, polybrominated diphenyl ethers (PBDEs), and perfluoroalkyl substances (PFAS), and found that higher exposure levels were linked to increased MetS risk scores. Conversely, high- and low-molecular weight phthalate mixtures were associated with lower MetS scores. The study also identified associations between EDC exposure and elevated levels of proinflammatory proteins, amino acids, and altered glycerophospholipids, which were linked to increased MetS risk. The findings suggest that exposure to widespread EDC mixtures during pregnancy may contribute to adverse metabolic health in children and could play a role in the ongoing rise of MetS across the life course. The study used a Bayesian weighted quantile sum regression approach to assess the associations between EDC mixtures and MetS risk scores, and identified specific chemical contributors to these associations. The study also found sex-specific effects, with certain chemicals having different associations in males and females. Overall, the study highlights the importance of considering EDC mixtures in assessing health risks and underscores the need for further research to understand the mechanisms underlying these associations.