This study describes the preparation of phospholipid polymers and their properties as polymer hydrogel membranes. A methacrylate monomer with a phospholipid polar group, 2-methacryloyloxyethyl phosphorylcholine (MPC), was synthesized using an improved method with good yield. MPC was copolymerized with n-butyl methacrylate (BMA) to form poly(MPC-co-BMA). The resulting polymer membranes were prepared by solution casting and exhibited good water absorption and hydrogel properties even with a low MPC mole fraction. The water content of the hydrogel membrane increased with higher MPC units and higher temperatures, attributed to the highly hydrophilic phospholipid polar group in the copolymer. Water-soluble organic compounds and proteins with molecular weights below 10^4 permeated through the hydrogel membrane, but proteins with molecular weights above 10^5 did not. The synthesis of MPC involved a series of chemical reactions, including the formation of OPEMA from COP and HEMA, followed by reaction with trimethylamine. The structure of MPC was confirmed by NMR and IR spectroscopy. The copolymerization of MPC and BMA was carried out in a methanol-THF mixture, resulting in a polymer with a molecular weight of at least 1.2 × 10^4. The equilibrium water content of the membrane increased with MPC composition, and the water content increased with temperature, showing a temperature response. The permeation of solutes through the membrane was influenced by temperature and molecular weight of the solute, with smaller molecules permeating more easily. The membrane showed good blood compatibility and could prevent the passage of large molecules like bovine γ-globulin, making it a promising material for biomedical applications.This study describes the preparation of phospholipid polymers and their properties as polymer hydrogel membranes. A methacrylate monomer with a phospholipid polar group, 2-methacryloyloxyethyl phosphorylcholine (MPC), was synthesized using an improved method with good yield. MPC was copolymerized with n-butyl methacrylate (BMA) to form poly(MPC-co-BMA). The resulting polymer membranes were prepared by solution casting and exhibited good water absorption and hydrogel properties even with a low MPC mole fraction. The water content of the hydrogel membrane increased with higher MPC units and higher temperatures, attributed to the highly hydrophilic phospholipid polar group in the copolymer. Water-soluble organic compounds and proteins with molecular weights below 10^4 permeated through the hydrogel membrane, but proteins with molecular weights above 10^5 did not. The synthesis of MPC involved a series of chemical reactions, including the formation of OPEMA from COP and HEMA, followed by reaction with trimethylamine. The structure of MPC was confirmed by NMR and IR spectroscopy. The copolymerization of MPC and BMA was carried out in a methanol-THF mixture, resulting in a polymer with a molecular weight of at least 1.2 × 10^4. The equilibrium water content of the membrane increased with MPC composition, and the water content increased with temperature, showing a temperature response. The permeation of solutes through the membrane was influenced by temperature and molecular weight of the solute, with smaller molecules permeating more easily. The membrane showed good blood compatibility and could prevent the passage of large molecules like bovine γ-globulin, making it a promising material for biomedical applications.