This study examines the prevalence and associated factors of long COVID symptoms among U.S. adults using data from the 2022 Behavioral Risk Factor Surveillance System (BRFSS). The study found that over 21% of adults who have had COVID-19 reported symptoms consistent with long COVID, with the most common symptoms being fatigue (26.2%), difficulty breathing (18.9%), and loss of taste or smell (17.0%). Long COVID was more prevalent among younger adults, females, American Indian or Alaska Native and other/multi-race groups, those with lower incomes, smokers, and individuals with disabilities or depression. The prevalence of long COVID was higher among unvaccinated adults (25.6%) compared to vaccinated adults (21.6%). The study highlights the importance of vaccination, early treatment, and targeted interventions to address disparities and support those experiencing long COVID.This study examines the prevalence and associated factors of long COVID symptoms among U.S. adults using data from the 2022 Behavioral Risk Factor Surveillance System (BRFSS). The study found that over 21% of adults who have had COVID-19 reported symptoms consistent with long COVID, with the most common symptoms being fatigue (26.2%), difficulty breathing (18.9%), and loss of taste or smell (17.0%). Long COVID was more prevalent among younger adults, females, American Indian or Alaska Native and other/multi-race groups, those with lower incomes, smokers, and individuals with disabilities or depression. The prevalence of long COVID was higher among unvaccinated adults (25.6%) compared to vaccinated adults (21.6%). The study highlights the importance of vaccination, early treatment, and targeted interventions to address disparities and support those experiencing long COVID.