This study estimates the prevalence of congenital heart defects (CHD) in metropolitan Atlanta from 1998 to 2005 using data from the Metropolitan Atlanta Congenital Defects Program (MACDP), a population-based surveillance system. The study found that the overall prevalence of CHD was 81.4 per 10,000 births, with the most common defects being muscular ventricular septal defect (VSD), perimembranous VSD, and secundum atrial septal defect (ASD). The prevalence of tetralogy of Fallot (TOF) was twice that of transposition of the great arteries (TGA). The study also identified associations between certain CHD and maternal age, multiple gestation, and sex. The prevalence estimates were based on a standardized nomenclature and classification system, allowing for comparisons across populations and time. The study highlights the importance of accurate prevalence estimates for understanding variations in CHD occurrence. However, the study acknowledges limitations, including potential underreporting of certain cases and the impact of diagnostic methods on prevalence estimates. The findings suggest that CHD prevalence in Atlanta is comparable to previously reported estimates, with some differences in specific defect prevalences. The study also notes that older maternal age and multiple gestation pregnancies are associated with a higher prevalence of certain CHD. Overall, the study provides valuable insights into the prevalence and characteristics of CHD in a specific population.This study estimates the prevalence of congenital heart defects (CHD) in metropolitan Atlanta from 1998 to 2005 using data from the Metropolitan Atlanta Congenital Defects Program (MACDP), a population-based surveillance system. The study found that the overall prevalence of CHD was 81.4 per 10,000 births, with the most common defects being muscular ventricular septal defect (VSD), perimembranous VSD, and secundum atrial septal defect (ASD). The prevalence of tetralogy of Fallot (TOF) was twice that of transposition of the great arteries (TGA). The study also identified associations between certain CHD and maternal age, multiple gestation, and sex. The prevalence estimates were based on a standardized nomenclature and classification system, allowing for comparisons across populations and time. The study highlights the importance of accurate prevalence estimates for understanding variations in CHD occurrence. However, the study acknowledges limitations, including potential underreporting of certain cases and the impact of diagnostic methods on prevalence estimates. The findings suggest that CHD prevalence in Atlanta is comparable to previously reported estimates, with some differences in specific defect prevalences. The study also notes that older maternal age and multiple gestation pregnancies are associated with a higher prevalence of certain CHD. Overall, the study provides valuable insights into the prevalence and characteristics of CHD in a specific population.