This systematic review examines the prevalence and persistence of depression in patients who have survived an acute myocardial infarction (AMI). The study found that approximately 19.8% of patients hospitalized for AMI had major depression, as determined by structured interviews. Using the Beck Depression Inventory (BDI), the prevalence of clinically significant depressive symptoms was 31.1%, while using the Hospital Anxiety and Depression Scale (HADS), it was 15.5% for a score of ≥8 and 7.3% for a score of ≥11. These differences in prevalence rates are likely due to variations in assessment methods. Depression is common and persistent in AMI survivors, with a significant proportion continuing to be depressed in the year after discharge. However, the limited number of studies and variable follow-up times made it difficult to specify prevalence rates at specific time points. The review highlights the importance of assessing depression in AMI patients, as it is associated with increased mortality and poor recovery. The study recommends using validated questionnaires like the BDI for initial screening, followed by structured clinical interviews for further assessment. The findings suggest that depression is more prevalent than previously thought in AMI patients, and that early identification and treatment are crucial for improving outcomes. The review also notes that the prevalence of depression in AMI patients is higher than in the general population, emphasizing the need for targeted interventions. The study concludes that depression is a significant issue in AMI survivors and that further research is needed to better understand its impact and develop effective treatment strategies.This systematic review examines the prevalence and persistence of depression in patients who have survived an acute myocardial infarction (AMI). The study found that approximately 19.8% of patients hospitalized for AMI had major depression, as determined by structured interviews. Using the Beck Depression Inventory (BDI), the prevalence of clinically significant depressive symptoms was 31.1%, while using the Hospital Anxiety and Depression Scale (HADS), it was 15.5% for a score of ≥8 and 7.3% for a score of ≥11. These differences in prevalence rates are likely due to variations in assessment methods. Depression is common and persistent in AMI survivors, with a significant proportion continuing to be depressed in the year after discharge. However, the limited number of studies and variable follow-up times made it difficult to specify prevalence rates at specific time points. The review highlights the importance of assessing depression in AMI patients, as it is associated with increased mortality and poor recovery. The study recommends using validated questionnaires like the BDI for initial screening, followed by structured clinical interviews for further assessment. The findings suggest that depression is more prevalent than previously thought in AMI patients, and that early identification and treatment are crucial for improving outcomes. The review also notes that the prevalence of depression in AMI patients is higher than in the general population, emphasizing the need for targeted interventions. The study concludes that depression is a significant issue in AMI survivors and that further research is needed to better understand its impact and develop effective treatment strategies.